INT196392

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.94
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
liver 6
hepatocytes 2
hearts 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 70 96.16 Very High Very High Very High
ischemia 6 92.36 High High
Kinase C 40 87.88 High High
Inflammation 25 74.48 Quite High
Pain 1 73.12 Quite High
Multiple sclerosis 2 61.12 Quite High
Action potential 1 54.96 Quite High
cytokine 6 41.60 Quite Low
tolerance 17 28.00 Quite Low
potassium channel 76 25.88 Quite Low
Disease Link Frequency Relevance Heat
Death 19 98.72 Very High Very High Very High
Reperfusion Injury 31 98.20 Very High Very High Very High
Wound Healing 29 96.56 Very High Very High Very High
Diabetes Mellitus 172 94.00 High High
Stress 130 92.96 High High
Cv Unclassified Under Development 72 92.36 High High
Diabetes Complications 8 90.96 High High
Impaired Glucose Tolerance 14 90.88 High High
Parkinson's Disease 120 90.16 High High
Toxicity 43 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that AdSOD1 treatment reduced the increased ROS in the liver of db/db mice to a level compatible with that of db/m mice.


Negative_regulation (reduced) of Positive_regulation (increased) of ROS in liver
1) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.15 Pain Relevance 0
Estimation of ROS generation in the liver revealed that gold nanoparticles blocked the high glucose-induced increase in ROS generation to a maximum extent in the liver which is shown in Figure 5.
Negative_regulation (blocked) of Positive_regulation (generation) of ROS in liver
2) Confidence 0.16 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 1.04 Pain Relevance 0
Estimation of ROS generation in the liver revealed that gold nanoparticles blocked the high glucose-induced increase in ROS generation to a maximum extent in the liver which is shown in Figure 5.
Negative_regulation (blocked) of Positive_regulation (increase) of ROS in liver
3) Confidence 0.16 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 1.03 Pain Relevance 0
Furthermore, hearts from Cx43-deficient mice showed no protection from reperfusion injury by either IP [261] or diazoxide [247] and in the latter case the ability of diazoxide to increase ROS was also abolished.
Negative_regulation (abolished) of Positive_regulation (increase) of ROS in hearts associated with reperfusion injury
4) Confidence 0.07 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.60 Pain Relevance 0.19
The increased ROS levels experienced by cells in wounded tissue may be exacerbated by the depletion of antioxidant enzymes including Cu/Zn superoxide dismutase (SOD1) and glutathione peroxidase [19].
Negative_regulation (depletion) of Positive_regulation (increased) of ROS
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 0.73 Pain Relevance 0.14
Recently, it has been reported that the APAP-induced reactive oxygen species (ROS) generation followed by lipid peroxidation in mouse primary hepatocytes induced cell death, and pretreatment with melatonin known as a potent antioxidant suppressed the increase in ROS and lipid peroxides, resulting in prevention of cell death [58].
Negative_regulation (suppressed) of Positive_regulation (increase) of ROS in hepatocytes associated with paracetamol and death
6) Confidence 0.04 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2803132 Disease Relevance 0.45 Pain Relevance 0.56
reduce ROS induced by an age-related overload of Ca2+ in
Negative_regulation (reduce) of Positive_regulation (induced) of ROS
7) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.71 Pain Relevance 0
Overexpression of CRIF1 enhanced both basal and H2O2-induced ROS accumulation, and CRIF1 knockdown reduced both basal and H2O2-induced ROS accumulation (Fig. 8, A and B).
Negative_regulation (reduced) of Positive_regulation (accumulation) of ROS
8) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0.23 Pain Relevance 0

General Comments

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