INT196393

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.24
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd86)
Anatomy Link Frequency
dendritic cells 2
CD86 1
enterocyte 1
B cell 1
Cd86 (Mus musculus)
Pain Link Frequency Relevance Heat
Etanercept 34 100.00 Very High Very High Very High
Infliximab 35 99.90 Very High Very High Very High
abatacept 54 87.20 High High
Arthritis 15 85.08 High High
tolerance 3 83.68 Quite High
qutenza 3 82.08 Quite High
rheumatoid arthritis 66 73.92 Quite High
psoriasis 4 71.12 Quite High
cytokine 34 66.96 Quite High
Crohn's disease 16 61.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 67 100.00 Very High Very High Very High
Autoimmune Disease 20 99.96 Very High Very High Very High
Colitis 38 96.12 Very High Very High Very High
Disease 197 95.24 Very High Very High Very High
Aging 19 93.60 High High
Stress 43 91.28 High High
Arthritis 10 85.08 High High
Motor Neuron Diseases 1 83.84 Quite High
Immunization 5 83.60 Quite High
Cognitive Disorder 9 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This change may be important because CD86 appears to be the dominant co-stimulatory ligand in a number of experimental models, and, in treating mouse models of autoimmune disease, inhibition of CD86 was more effective than inhibition of CD80 [5].
Negative_regulation (inhibition) of CD86 in CD86 associated with autoimmune disease
1) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833980 Disease Relevance 0.37 Pain Relevance 0.30
Studies conducted by Tellander and coworkers [45] indicate that antibody titres are also decreased when CD80/CD86 are blocked, indicating the importance of this co-stimulation pathway in B cell help.
Negative_regulation (blocked) of CD86 in B cell
2) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 0.68 Pain Relevance 0.25
In APC/T cell co-cultures, mature dendritic cells (DC) were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation.
Negative_regulation (blocking) of B7 in dendritic cells
3) Confidence 0.21 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0
In APC/T cell co-cultures, mature dendritic cells (DC) were less efficient than immature DC in their ability to support Th17 cell differentiation, while CTLA4-Ig, an agent blocking CD28/B7 and CTLA4/B7 interactions, facilitated both murine and human Th17 differentiation.
Negative_regulation (blocking) of B7 in dendritic cells
4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2658739 Disease Relevance 0.14 Pain Relevance 0
generates free radicals, leading to the disruption of the ETC and
Negative_regulation (disruption) of ETC
5) Confidence 0.02 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.78 Pain Relevance 0
Both anti-TNF strategies, IFX and ETC, were equally effective in suppressing enterocyte apoptosis, most likely by inactivation of circulating TNF-?.



Negative_regulation (inactivation) of ETC in enterocyte associated with infliximab, apoptosis and etanercept
6) Confidence 0.02 Published 2008 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC2452978 Disease Relevance 1.17 Pain Relevance 0.48
Inhibition of the activity of complex I in the ETC, e.g. upon exposure to the pesticide rotenone (Rot), has been identified as one of the major pro-oxidative factors causing Parkinson's disease (PD) 14-16.
Negative_regulation (Inhibition) of ETC associated with disease
7) Confidence 0.01 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.52 Pain Relevance 0.08
In this study, using mouse hippocampal HT22 cells as in vitro model, we monitored the change of intracellular ROS level in response to the blockade of ETC at different complex, and measured changes of gene expression of antioxidant enzymes and phase II enzymes, also evaluated potential protective effect of selenium (Se) supplementation to the cells under this oxidative stress.
Negative_regulation (blockade) of ETC associated with stress
8) Confidence 0.01 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1925139 Disease Relevance 0.09 Pain Relevance 0
When the ETC is blocked by an inhibitor, the reduction state of electron carriers increases on the substrate side of the inhibitor, while those on the oxygen side become more oxidized.
Negative_regulation (blocked) of ETC
9) Confidence 0.01 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.35 Pain Relevance 0.06

General Comments

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