INT19641

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1990
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 1.12
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
striatum 5
neurons 4
hippocampus 4
nucleus accumbens 3
interstitial cells 2
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
qutenza 3 99.82 Very High Very High Very High
Hippocampus 8 99.68 Very High Very High Very High
Nucleus accumbens 14 99.24 Very High Very High Very High
adenocard 8 98.92 Very High Very High Very High
Morphine 14 97.36 Very High Very High Very High
nMDA receptor 1 96.72 Very High Very High Very High
primary afferent fibers 1 95.08 Very High Very High Very High
antagonist 7 92.96 High High
ischemia 2 92.84 High High
Disease Link Frequency Relevance Heat
Hypoxia 6 98.36 Very High Very High Very High
Injury 4 97.68 Very High Very High Very High
Cv Unclassified Under Development 2 92.84 High High
Convulsion 2 67.88 Quite High
Pain 1 66.08 Quite High
Epilepsy 2 57.20 Quite High
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals treated neonatally with capsaicin display reduced preproenkephalin gene expression in nucleus caudalis neurons.
Negative_regulation (reduced) of Gene_expression (expression) of preproenkephalin in neurons associated with qutenza
1) Confidence 0.58 Published 1990 Journal J. Comp. Neurol. Section Abstract Doc Link 2081812 Disease Relevance 0.07 Pain Relevance 0.32
Using in situ hybridization and northern blot analysis, we found that the KD significantly decreases the level of PENK gene expression induced by KA of the granular cells in the hippocampus.
Negative_regulation (decreases) of Gene_expression (expression) of PENK in hippocampus associated with hippocampus
2) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.13 Pain Relevance 0.24
These results suggest that the KD suppresses KA-induced activation of JNK signaling pathways, followed by a decrease of PENK gene expression in the hippocampus, thereby resulting in antiepileptic effects.
Negative_regulation (decrease) of Gene_expression (expression) of PENK in hippocampus associated with hippocampus
3) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.05 Pain Relevance 0.23
These compared changes in various indexes of enkephalin neuron activity suggest that stimulation of GABAA receptors depresses enkephalin release immediately and for several hours, whereas preproenkephalin gene expression is decreased in a somewhat delayed and longer lasting manner.
Negative_regulation (decreased) of Gene_expression (expression) of preproenkephalin in neuron associated with enkephalin
4) Confidence 0.52 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.66
The above results indicate that repeated morphine leads to long-lasting upregulation of the PDYN gene expression in the mouse nucleus accumbens and striatum; on the other hand, the PENK and D2 mRNA gene expressions are either inhibited or remain unchanged, significant changes being observed in the nucleus accumbens only.
Negative_regulation (inhibited) of Gene_expression (expressions) of PENK in nucleus accumbens associated with nucleus accumbens and morphine
5) Confidence 0.51 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.92
Proenkephalin gene expression in testicular interstitial cells is down-regulated coincident with the appearance of pachytene spermatocytes.
Negative_regulation (down-regulated) of Gene_expression (expression) of Proenkephalin gene in interstitial cells associated with enkephalin
6) Confidence 0.42 Published 1994 Journal Endocrinology Section Title Doc Link 7925115 Disease Relevance 0 Pain Relevance 0.30
In isolated neostriatal slices in which the expression of the PEnk gene had been down-regulated, NMDA increased the number of cells which expressed the gene in a time-dependent manner.
Negative_regulation (down-regulated) of Gene_expression (expression) of PEnk gene
7) Confidence 0.39 Published 1999 Journal Cereb. Cortex Section Abstract Doc Link 10426412 Disease Relevance 0 Pain Relevance 0.09
Ginsenosides attenuate methamphetamine-induced behavioral side effects in mice via activation of adenosine A2A receptors: possible involvements of the striatal reduction in AP-1 DNA binding activity and proenkephalin gene expression.
Spec (possible) Negative_regulation (reduction) of Gene_expression (expression) of proenkephalin gene associated with adenocard and enkephalin
8) Confidence 0.27 Published 2005 Journal Behav. Brain Res. Section Title Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.46
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Negative_regulation (reduced) of Gene_expression (expression) of proenkephalin mRNA in striatum
9) Confidence 0.20 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.29
The above results indicate that repeated morphine leads to long-lasting upregulation of the PDYN gene expression in the mouse nucleus accumbens and striatum; on the other hand, the PENK and D2 mRNA gene expressions are either inhibited or remain unchanged, significant changes being observed in the nucleus accumbens only.
Negative_regulation (inhibited) of in striatum Gene_expression (expressions) of PENK in nucleus accumbens associated with nucleus accumbens and morphine
10) Confidence 0.17 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9574833 Disease Relevance 0 Pain Relevance 0.92
Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury.
Negative_regulation (suppression) of Gene_expression (expression) of preproenkephalin mRNA in striatum associated with hypoxia, injury and enkephalin
11) Confidence 0.12 Published 1994 Journal J. Neurochem. Section Title Doc Link 8158136 Disease Relevance 0.87 Pain Relevance 0.46
Surprisingly, the expression of the PEnk gene in the glial progenitors of the subventricular zone as induced by PACAP38 was not affected by any of the three protein kinase inhibitors, but was blocked by the unspecific kinase inhibitor H7.
Negative_regulation (blocked) of Gene_expression (expression) of PEnk gene
12) Confidence 0.02 Published 2000 Journal Glia Section Abstract Doc Link 10756074 Disease Relevance 0 Pain Relevance 0
In the neocortical part of the slice cultures, the effect of PACAP38 on PEnk gene expression was inhibited only by H89 and PD98059.
Negative_regulation (effect) of Gene_expression (expression) of PEnk gene
13) Confidence 0.02 Published 2000 Journal Glia Section Abstract Doc Link 10756074 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox