INT196421

Context Info Confidence 0.24 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.17 Pain Relevance 0.15

mitochondrion (Cdk1) protein complex assembly (Cdk1) cytoplasm (Cdk1) mitosis (Cdk1) nucleus (Cdk1) cell cycle (Cdk1)

Cdk1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 1 92.76 cINOD 1 71.36 Inflammation 2 70.80 cerebral cortex 6 5.00 Eae 3 5.00 Hippocampus 2 5.00 imagery 2 5.00 palliative 1 5.00 anesthesia 1 5.00 transdermal 1 5.00

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 1 92.76 Brain Injury 1 92.12 Convulsion 1 90.00 Disease 110 85.52 Aging 11 83.00 INFLAMMATION 2 70.80 Renal Cancer 1 58.96 Targeted Disruption 38 54.92 Brain Tumor 1 53.28 Glioma 1 51.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

found in a plant native to India, Dysoxylum binectariferum, is a potent inhibitor of most CDKs, including CDK1, CDK2, CDK4, and CDK7 [73].

Negative_regulation (inhibitor) of CDK1

1) Confidence 0.24 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.11 Pain Relevance 0.15

Meanwhile, mutant Htt expression did not suppress activities of other kinases such as Cdk1/Cdc2 or MAPK/extracellular-regulated kinase (ERK; Fig. 5 F), supporting the view that the effect of mutant Htt on DNA–PK could be specific to some extent.

Neg (not) Negative_regulation (suppress) of Cdk1

2) Confidence 0.12 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.05 Pain Relevance 0

General Comments

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