INT196424

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.34
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
stroma 1
proximal 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 87.24 High High
cINOD 8 85.68 High High
corticosteroid 1 84.80 Quite High
ischemia 1 80.40 Quite High
Inflammatory stimuli 2 79.44 Quite High
aspirin 3 74.96 Quite High
cva 2 7.28 Low Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 7 99.78 Very High Very High Very High
Parathyroid Cancer 40 97.28 Very High Very High Very High
Apoptosis 21 95.08 Very High Very High Very High
Carcinoma 11 91.92 High High
Cancer 100 88.08 High High
Retinoblastoma 3 87.60 High High
INFLAMMATION 19 87.24 High High
Nasopharynx Cancer 53 82.64 Quite High
Renal Cancer 1 82.40 Quite High
Cv Unclassified Under Development 1 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A well-conserved consensus Sox binding sequence was identified in cyclin D1 proximal promoter, located at approximately ?
cyclin D1 Binding (binding) of in proximal
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
To determine if cyclin D1 is a direct transcriptional target Sox17, the regulatory region of cyclin D1 was examined for putative Sox binding sites.
cyclin D1 Spec (examined) Binding (binding) of
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
The corresponding stroma in the adenomas showed no immunoreactivity for CD1.
CD1 Neg (no) Binding (immunoreactivity) of in stroma associated with adenoma
3) Confidence 0.12 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 1.09 Pain Relevance 0
of this inhibition is a decrease in cyclin D1, the binding partner
cyclin D1 Binding (binding) of
4) Confidence 0.12 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.16 Pain Relevance 0.13
However, Van Poznak et al. and Zhang et al. suggested that gossypol-induced cell cycle arrest is associated with alterations of p21, cyclin D1, and p53 and showed that p21 is the first target of gossypol to inhibit cell growth in vivo [9,20].
cyclin D1 Binding (alterations) of
5) Confidence 0.10 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.36 Pain Relevance 0
B also induces the expression of cyclin D1, which helps in G1-to-S-phase progression by binding directly to its promoter(Guttridgeet al.1999).Inhibition of NF?
cyclin D1 Binding (binding) of
6) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.72 Pain Relevance 0.34

General Comments

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