INT19646

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.27
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KLRD1)
Anatomy Link Frequency
T cell 8
NK cell 1
KLRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 16 99.64 Very High Very High Very High
rheumatoid arthritis 31 96.48 Very High Very High Very High
lidocaine 7 96.24 Very High Very High Very High
Etanercept 5 90.36 High High
Infliximab 12 89.76 High High
aspirin 1 87.32 High High
Inflammation 46 86.96 High High
cytokine 44 83.68 Quite High
Arthritis 5 77.84 Quite High
Multiple sclerosis 1 76.48 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 65 99.92 Very High Very High Very High
Fatigue 26 99.64 Very High Very High Very High
Disease 32 99.12 Very High Very High Very High
Autoimmune Disease 22 99.00 Very High Very High Very High
Rheumatoid Arthritis 38 96.48 Very High Very High Very High
Hypersensitivity 13 94.16 High High
INFLAMMATION 47 86.96 High High
Graft Vs Host Disease 120 82.92 Quite High
Arthropathy 1 82.24 Quite High
Inflammatory Bowel Disease 1 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulatory compounds induced a down-regulation of the T cell receptor, demonstrating that these non-peptide antigens are recognized by the T cell receptor itself.
cell receptor Binding (recognized) of in T cell
1) Confidence 0.04 Published 1999 Journal J. Invest. Dermatol. Section Abstract Doc Link 9989796 Disease Relevance 0.16 Pain Relevance 0.83
Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines.
cell receptor Binding (Characterization) of in T cell associated with autoimmune disease
2) Confidence 0.03 Published 2000 Journal J. Neuroimmunol. Section Title Doc Link 11024529 Disease Relevance 0.98 Pain Relevance 0.14
The broadly reactive clone OFB2 allowed us to propose a model, suggesting that the structure of the amine side chain of local anesthetics is essential for recognition by the T cell receptor.
cell receptor Binding (recognition) of in T cell associated with local anesthetic
3) Confidence 0.03 Published 1999 Journal J. Invest. Dermatol. Section Abstract Doc Link 9989796 Disease Relevance 0.06 Pain Relevance 0.67
Alloreactivity in the setting of matched siblings then involves the recognition of different nonself peptides bound in the T cell receptor and carried by the recipient MHC.
cell receptor Binding (bound) of in T cell
4) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2018687 Disease Relevance 0.32 Pain Relevance 0
Interaction with NK cell gene set expression was also a distinguishing feature in particular for ISF.
NK cell gene Binding (Interaction) of in NK cell associated with fatigue
5) Confidence 0.01 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.86 Pain Relevance 0
Rather, some drugs may bind directly and reversibly to immune receptors like the major histocompatibility complex (MHC) or the T cell receptor (TCR), thereby stimulating the cells similar to a pharmacological activation of other receptors.
cell receptor Binding (bind) of in T cell
6) Confidence 0.01 Published 2006 Journal Allergol Int Section Abstract Doc Link 17075282 Disease Relevance 0.14 Pain Relevance 0.14
The antigen is recognized by T cells by means of their antigen-specific T cell receptor (TCR).
cell receptor Binding (recognized) of in T cells
7) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.48 Pain Relevance 0.13
First, B cells may act as antigen presentation cells and activate T cells through the interaction between the MHC class II molecule and the T cell receptor.
cell receptor Binding (interaction) of in T cells
8) Confidence 0.00 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581826 Disease Relevance 0.54 Pain Relevance 0.29
To date, no genetically determined differences in the HLA-B27 molecule, or in the T cell receptor which recognizes antigen in the context of HLA-B27, have been consistently shown to be associated with the presence of disease.
cell receptor Binding (associated) of in T cell associated with disease
9) Confidence 0.00 Published 1990 Journal J Rheumatol Suppl Section Abstract Doc Link 2082018 Disease Relevance 0.74 Pain Relevance 0.15

General Comments

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