INT196523

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.94
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMP2, TIMP1) peptidase activity (MMP2) extracellular space (MMP2)
aging (TIMP1) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2)
Anatomy Link Frequency
cartilage 1
MMP2 (Homo sapiens)
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 45 98.92 Very High Very High Very High
metalloproteinase 106 98.12 Very High Very High Very High
Potency 2 43.00 Quite Low
Dysuria 2 18.16 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 46 98.92 Very High Very High Very High
Renal Cancer 8 97.04 Very High Very High Very High
Transitional Cell Carcinoma 52 95.60 Very High Very High Very High
Cancer 72 87.28 High High
Aggression 4 86.48 High High
Bladder Cancer 58 85.48 High High
Arthritis 5 82.72 Quite High
Disease 11 81.72 Quite High
Injury 1 77.96 Quite High
Metastasis 22 56.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies have shown that TIMP1 binds preferably to MMP9 and TIMP2 to MMP2 [18,19].
MMP2 Binding (binds) of TIMP1
1) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.68 Pain Relevance 0.52
Studies have shown that TIMP1 binds preferably to MMP9 and TIMP2 preferably to MMP2 [18].
MMP2 Binding (binds) of TIMP1
2) Confidence 0.43 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.82 Pain Relevance 0.22
None of the commercial chondroprotective drugs are reported to inhibit hyaluronidase; whereas the drugs nimusulide (23) and doxycycline (24) inhibit activities of collagenase and gelatinase in cartilage derived from osteoarthritis patients in vitro.
gelatinase Binding (activities) of collagenase in cartilage associated with osteoarthritis
3) Confidence 0.01 Published 2008 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2529383 Disease Relevance 0.44 Pain Relevance 0.11

General Comments

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