INT196575

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk14, Il1a) mitochondrion (Mapk14) cell morphogenesis (Mapk14)
response to stress (Mapk14) cytoplasm (Mapk14) extracellular space (Il1a)
Mapk14 (Rattus norvegicus)
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 37 100.00 Very High Very High Very High
Arthritis 32 98.32 Very High Very High Very High
cytokine 9 97.00 Very High Very High Very High
metalloproteinase 4 83.68 Quite High
Inflammation 53 83.48 Quite High
Pain 8 55.08 Quite High
Dorsal horn 5 10.40 Low Low
Spinal cord 30 5.00 Very Low Very Low Very Low
Central nervous system 29 5.00 Very Low Very Low Very Low
Etanercept 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 17 98.32 Very High Very High Very High
INFLAMMATION 55 83.48 Quite High
Experimental Arthritis 22 81.32 Quite High
Pain 7 55.08 Quite High
Pressure And Volume Under Development 9 44.44 Quite Low
Rheumatoid Arthritis 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3C shows that the IT p38 inhibitor significantly decreased synovial IL-1 (p = 0.025) and IL-6 (p = 0.006) mRNA in arthritis and there was a trend toward a decrease in TNF?
Negative_regulation (inhibitor) of IT p38 Negative_regulation (decreased) of Gene_expression (synovial) of IL-1 associated with arthritis and intrathecal
1) Confidence 0.04 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.44 Pain Relevance 0.77

General Comments

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