INT196586

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.02
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) intracellular (TNF)
extracellular matrix organization (TNF) response to stress (Mapk14) cytoplasm (Mapk14)
Mapk14 (Rattus norvegicus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 49 100.00 Very High Very High Very High
Central nervous system 43 100.00 Very High Very High Very High
cytokine 23 99.04 Very High Very High Very High
Arthritis 56 98.56 Very High Very High Very High
Etanercept 13 96.96 Very High Very High Very High
Inflammation 156 95.16 Very High Very High Very High
Spinal cord 51 90.00 High High
Pain 14 89.56 High High
Inflammatory mediators 2 76.68 Quite High
Eae 4 69.76 Quite High
Disease Link Frequency Relevance Heat
Arthritis 41 98.56 Very High Very High Very High
Experimental Arthritis 29 96.32 Very High Very High Very High
INFLAMMATION 157 95.16 Very High Very High Very High
Pain 13 89.56 High High
Stress 6 72.32 Quite High
Nervous System Injury 2 69.80 Quite High
Neuropathic Pain 7 66.40 Quite High
Necrosis 3 63.32 Quite High
Cancer 3 62.96 Quite High
Ganglion Cysts 2 60.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that p38 inhibition also suppresses TNF?
Negative_regulation (inhibition) of p38 Negative_regulation (suppresses) of TNF
1) Confidence 0.04 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.94 Pain Relevance 1.10
Because p38 inhibition in the CNS also suppressed intrathecal TNF, the most likely mechanism is that TNF both induces and is induced by p38 activation.
Negative_regulation (inhibition) of p38 Negative_regulation (suppressed) of TNF associated with central nervous system and intrathecal
2) Confidence 0.04 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927688 Disease Relevance 1.08 Pain Relevance 0.98

General Comments

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