INT196603

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.75
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (STK11) mitochondrion (STK11) small molecule metabolic process (STK11)
nucleus (STK11) cell cycle (STK11) protein complex (STK11)
Anatomy Link Frequency
pigmentation 1
STK11 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 76.04 Quite High
Chronic pancreatitis 3 69.00 Quite High
COX2 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 70 100.00 Very High Very High Very High
Pancreatic Cancer 114 99.84 Very High Very High Very High
Pigment Disorder 2 99.24 Very High Very High Very High
Cancer 117 98.88 Very High Very High Very High
Polyps 87 97.16 Very High Very High Very High
Hyperplasia 17 95.04 Very High Very High Very High
Adenoma 63 88.32 High High
Colon Cancer 5 87.44 High High
Disease 12 84.36 Quite High
Carcinoma 60 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative analyses of LKB1 expressions in cultured and microdissected cells, and correlation analyses between LKB1 and LMO4 in pancreatic carcinogenesis
Gene_expression (expressions) of LKB1
1) Confidence 0.55 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.23 Pain Relevance 0
To investigate the potential role of LMO4 in pancreatic carcinogenesis, we measured LKB1 mRNA expression in cultured and microdissected cells and investigated any correlation between LKB1 and LMO4 expression.
Gene_expression (expression) of LKB1
2) Confidence 0.55 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 0.78 Pain Relevance 0
In the last decade, the advancement of molecular biology improved the understanding of the pathogenesis of pancreatic cancer and characterized a number of genes that mutated in pancreatic cancers, such as somatic mutations in genes INK4A(CDKN2A), TP53, DPC4, BRCA1/2, STK11, APC, KRAS and ATM and PALB2 are found in pancreatic cancers [10]–[18].
Gene_expression (found) of STK11 associated with pancreatic cancer
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912284 Disease Relevance 1.37 Pain Relevance 0.07
In the regulation of energy levels the protein product of STK11 acts in a pathway to inhibit AMP-activated protein kinase which then signals downstream to inhibit the mTOR (mammalian target of rapamycin) pathway [30].
Gene_expression (product) of STK11
4) Confidence 0.46 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 2.04 Pain Relevance 0.08
The diagnosis of PJS can be made using the WHO criteria: [1] 3 or more histologically confirmed Peutz-Jeghers type polyps (PJP), or, [2] any number of PJP with a family history of PJS, or, [3] characteristic, prominent, mucocutaneous pigmentation with a family history of PJS, or, [4] any number of PJP and characteristic, prominent mucocutaneous pigmentation.
Gene_expression (made) of PJS in pigmentation associated with syndrome and polyps
5) Confidence 0.29 Published 2008 Journal Cases J Section Body Doc Link PMC2515291 Disease Relevance 1.33 Pain Relevance 0
IS and PJS conducted statistical analyses.
Spec (analyses) Gene_expression (conducted) of PJS
6) Confidence 0.26 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1562407 Disease Relevance 0 Pain Relevance 0

General Comments

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