INT196608

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.11
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, CFTR) transport (CFTR) intracellular (TNF)
enzyme binding (CFTR) extracellular matrix organization (TNF) protein complex (CFTR)
Anatomy Link Frequency
HT-29 1
T84 1
TNF (Homo sapiens)
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 85.84 High High
Inflammatory mediators 40 56.32 Quite High
Inflammation 68 50.00 Quite Low
adenocard 10 11.32 Low Low
bradykinin 20 5.00 Very Low Very Low Very Low
sodium channel 18 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 112 55.92 Quite High
Hypersensitivity 8 49.04 Quite Low
Colitis 6 49.04 Quite Low
Heart Rate Under Development 22 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Diarrhoea 16 5.00 Very Low Very Low Very Low
Cystic Fibrosis 12 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Pyelonephritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments with the gut derived epithelial cell lines T84 and HT-29 showed that interferon gamma and TNF both independently and if applied together synergistically, reduce CFTR mRNA by destabilization of transcripts and with prolonged [> 24 hour] exposure also CFTR protein on the cell surface.
TNF Negative_regulation (reduce) of CFTR mRNA in HT-29
1) Confidence 0.16 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.06 Pain Relevance 0.07
Experiments with the gut derived epithelial cell lines T84 and HT-29 showed that interferon gamma and TNF both independently and if applied together synergistically, reduce CFTR mRNA by destabilization of transcripts and with prolonged [> 24 hour] exposure also CFTR protein on the cell surface.
TNF Negative_regulation (reduce) of CFTR mRNA in T84
2) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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