INT196624

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, SCNN1G) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
epithelial cells 2
TNF (Homo sapiens)
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 72.32 Quite High
Inflammatory mediators 20 65.60 Quite High
Inflammation 34 50.00 Quite Low
bradykinin 10 47.76 Quite Low
cytokine 21 33.92 Quite Low
sodium channel 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 56 65.20 Quite High
Heart Rate Under Development 11 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low
Cystic Fibrosis 6 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Pyelonephritis 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure of alveolar epithelial cells to TNF alpha by in vitro incubation [24hours], a condition which is known to change the physiological properties of alveolar epithelial cells significantly [19] seemed to reduce ENaC mRNA expression without impact on Na/K ATPase expression [44].
TNF Negative_regulation (reduce) of Transcription (expression) of ENaC in epithelial cells
1) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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