INT196625

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNF, SCNN1G) signal transduction (TNF) extracellular space (TNF)
extracellular region (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 69.80 Quite High
Inflammation 34 50.00 Quite Low
Inflammatory mediators 20 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
sodium channel 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 4 89.76 High High
Colitis 3 53.68 Quite High
INFLAMMATION 56 50.00 Quite Low
Pyelonephritis 4 22.16 Low Low
Urinary Tract Infection 1 17.28 Low Low
Hyponatremia 3 12.48 Low Low
Hyperkalemia 1 11.12 Low Low
Heart Rate Under Development 11 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This lack of response to aldosterone could be reproduced by incubation of healthy human colonic tissue with TNF and IFN gamma, which reduced electrogenic sodium transport and lead to a reduced upregulation of ENaC mRNA [89].
TNF Negative_regulation (reduced) of Positive_regulation (upregulation) of ENaC
1) Confidence 0.02 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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