INT196632

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.52
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) Golgi apparatus (F2RL1)
IL1B (Homo sapiens)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 69 100.00 Very High Very High Very High
Inflammatory mediators 24 98.96 Very High Very High Very High
Inflammatory response 6 85.28 High High
substance P 3 85.04 High High
Potency 1 75.12 Quite High
spastic colon 1 69.36 Quite High
Arthritis 5 68.16 Quite High
bradykinin 10 60.48 Quite High
cytokine 24 42.84 Quite Low
agonist 31 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 98 100.00 Very High Very High Very High
Functional Bowel Disorder 1 69.36 Quite High
Arthritis 5 68.16 Quite High
Asthma 3 67.72 Quite High
Disease 14 66.72 Quite High
Renal Disease 2 30.16 Quite Low
Multiple Sclerosis 1 25.76 Quite Low
Chronic Obstructive Pulmonary Disease 2 21.60 Low Low
Cancer 25 5.00 Very Low Very Low Very Low
Heart Rate Under Development 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-8 and receptor, IL-1, TNF-9) is consistent with a pro-inflammatory role for PAR2 activation, in contrast to the anti-inflammatory complement effects above.
IL-1 Positive_regulation (role) of PAR2 associated with inflammation
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.39 Pain Relevance 0.70
PAR2 are induced by TNF and IL-1 [42].
IL-1 Positive_regulation (induced) of PAR2
2) Confidence 0.01 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.13 Pain Relevance 0.14

General Comments

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