INT196647

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.79 Pain Relevance 0.24

extracellular space (IFNG) extracellular region (IFNG)

Anatomy Link Frequency Caco-2 2 IFNG (Homo sapiens) NA (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 42 96.44 Inflammation 68 83.76 Crohn's disease 2 53.92 Inflammatory mediators 40 39.60 bradykinin 20 5.00 sodium channel 18 5.00 fibrosis 12 5.00 adenocard 10 5.00 agonist 10 5.00 substance P 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 112 83.76 Diarrhoea 16 77.08 Inflammatory Bowel Disease 8 70.16 Cryptosporidiosis 2 55.60 Pyelonephritis 8 55.12 Disease 18 53.92 Urinary Tract Infection 2 50.24 Hyponatremia 6 45.44 Hyperkalemia 2 44.08 Colitis 6 34.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of the Na/K ATPase by IFN gamma was also observed in murine small intestine preparations and the intestinal epithelial Caco-2 cell line [58,59].

IFN gamma Negative_regulation (Inhibition) of Na in Caco-2

1) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.62 Pain Relevance 0.21

Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].

interferon gamma Negative_regulation (reduced) of Na in Caco-2

2) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

This test has worked.