INT196671

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 7 99.90 Very High Very High Very High
Inflammation 34 76.24 Quite High
cytokine 21 75.20 Quite High
TRP channel 1 49.04 Quite Low
Inflammatory response 3 10.96 Low Low
agonist 6 5.56 Low Low
Inflammatory mediators 20 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
sodium channel 9 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 7 99.90 Very High Very High Very High
Sepsis 4 89.60 High High
Heart Rate Under Development 15 87.84 High High
INFLAMMATION 56 76.24 Quite High
Cancer 6 74.00 Quite High
Necrosis 5 73.52 Quite High
Targeted Disruption 2 59.12 Quite High
Bacterial Pneumonia 1 43.20 Quite Low
Meningitis 3 38.52 Quite Low
Pneumonia 1 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased extrusion of K+ ions in the presence of 1-EBIO may locally build up an electrical gradient resulting in elevated ENaC activity.
Positive_regulation (resulting) of Positive_regulation (elevated) of ENaC
1) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.06 Pain Relevance 0
In isolated congenital CFTR dysfunction (cystic fibrosis) an increase in sodium transport by an increase in apical ENaC and basolateral Na/K ATPase activity in the airways can compensate for a reduction in alveolar chloride and sodium transport.
Positive_regulation (increase) of Positive_regulation (increase) of ENaC associated with fibrosis and cystic fibrosis
2) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.98 Pain Relevance 0.13

General Comments

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