INT196673

Context Info Confidence 0.36 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.62 Pain Relevance 0.08

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR) enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)

Anatomy Link Frequency T84 2 CFTR (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 42 84.96 Inflammation 68 50.00 Inflammatory mediators 40 42.08 bradykinin 20 5.68 sodium channel 18 5.00 fibrosis 12 5.00 adenocard 10 5.00 agonist 10 5.00 substance P 6 5.00 Inflammatory response 6 5.00

Disease Link Frequency Relevance Heat Pyelonephritis 8 94.16 Colitis 6 92.72 Urinary Tract Infection 2 89.28 Hyponatremia 6 84.48 Hyperkalemia 2 83.12 Hypoaldosteronism 2 60.40 Inflammatory Bowel Disease 8 50.72 INFLAMMATION 112 50.00 Natriuresis 4 36.72 Hypersensitivity 8 12.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interleukin-4 in contrast to the genetically closely linked interleukin -13 was able to reduce chloride secretion as assessed by 125 I efflux assay by down regulation of CFTR expression in the human intestinal cell line T84 in vitro [93].

Regulation (regulation) of Gene_expression (expression) of CFTR in T84

1) Confidence 0.36 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.53 Pain Relevance 0

A dichotomous effect on CFTR expression was noted for Interleukin 1beta.

Regulation (effect) of Gene_expression (expression) of CFTR

2) Confidence 0.36 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.09 Pain Relevance 0.08

General Comments

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