INT196674

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
Anatomy Link Frequency
epithelial cells 1
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 76.36 Quite High
substance P 6 65.32 Quite High
Inflammatory mediators 40 58.60 Quite High
Inflammation 68 50.00 Quite Low
bradykinin 20 40.76 Quite Low
sodium channel 18 5.00 Very Low Very Low Very Low
fibrosis 12 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 8 98.16 Very High Very High Very High
Colitis 6 60.24 Quite High
INFLAMMATION 112 58.20 Quite High
Heart Rate Under Development 22 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Diarrhoea 16 5.00 Very Low Very Low Very Low
Cystic Fibrosis 12 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Pyelonephritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged exposure of alveolar epithelial cells to TNF alpha by in vitro incubation [24hours], a condition which is known to change the physiological properties of alveolar epithelial cells significantly [19] seemed to reduce ENaC mRNA expression without impact on Na/K ATPase expression [44].
Transcription (expression) of ENaC in epithelial cells
1) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.06 Pain Relevance 0.06
In an ex vivo human colonic mucosa plus submucosa preparation of patients with ulcerative colitis aldosterone was unable to stimulate electrogenic sodium transport in the Ussing chamber or ENaC mRNA levels and protein expression [See figure 3].
Transcription (levels) of ENaC associated with inflammatory bowel disease
2) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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