INT196675

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.95
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR)
enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)
Anatomy Link Frequency
nasal 2
epithelial cells 1
CFTR (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 25 98.58 Very High Very High Very High
agonist 32 95.44 Very High Very High Very High
cytokine 42 86.00 High High
fibrosis 50 84.36 Quite High
adenocard 32 77.92 Quite High
Inflammation 70 60.72 Quite High
Chronic pancreatitis 2 50.60 Quite High
Pain 1 49.32 Quite Low
antagonist 4 42.52 Quite Low
Potency 2 37.08 Quite Low
Disease Link Frequency Relevance Heat
Nasal Polyps 38 99.68 Very High Very High Very High
Aplasia 1 85.68 High High
Cystic Fibrosis 49 84.36 Quite High
Metaplasia 1 81.12 Quite High
Fibrosis 1 69.84 Quite High
Exocrine Pancreatic Insufficiency 26 68.08 Quite High
INFLAMMATION 114 60.72 Quite High
Disease 19 59.68 Quite High
Diarrhoea 20 56.08 Quite High
Pancreatitis 2 50.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CFTR activator, genistein (24), did not induce a CFTR current, which may be attributed to an altered localization of CFTR in the nasal polyp (25).
Localization (localization) of CFTR in nasal associated with nasal polyps
1) Confidence 0.64 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.39 Pain Relevance 0.30
The CFTR activator, genistein (24), did not induce a CFTR current, which may be attributed to an altered localization of CFTR in the nasal polyp (25).
Localization (localization) of CFTR in nasal associated with nasal polyps
2) Confidence 0.52 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.39 Pain Relevance 0.30
Amiloride is used to block sodium channels and forskolin, a stimulator of the adenylate cyclase, which activates CFTR mediated chloride secretion through increase in intracellular cAMP, is used to test CFTR function.


Localization (secretion) of CFTR associated with sodium channel
3) Confidence 0.47 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0 Pain Relevance 0.05
Antagonistic effects may have IFN gamma because short-circuit current measurements in the Ussing chamber of bronchial epithelial cells showed that it decreases CFTR dependent chloride secretion significantly, which was associated with a reduction in CFTR mRNA [49].
Localization (secretion) of CFTR in epithelial cells
4) Confidence 0.47 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.18 Pain Relevance 0.15
Normal tissues secrete alkaline fluids but mutant CFTR expressing tissues secrete acidic fluids.
Localization (secrete) of CFTR
5) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621407 Disease Relevance 0.99 Pain Relevance 0.39

General Comments

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