INT196681

Context Info Confidence 0.34 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0.15

transport (CFTR) ATPase activity (CFTR) plasma membrane (CFTR) enzyme binding (CFTR) protein complex (CFTR) transmembrane transport (CFTR)

Anatomy Link Frequency epithelial cells 2 CFTR (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 21 86.40 Inflammation 34 60.72 Inflammatory mediators 20 14.24 substance P 3 13.40 bradykinin 10 5.00 sodium channel 9 5.00 fibrosis 6 5.00 adenocard 5 5.00 agonist 5 5.00 Inflammatory response 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 56 60.72 Disease 9 59.68 Diarrhoea 8 56.08 Volume Depletion And Dehydration 1 50.00 Pressure Volume 2 Under Development 2 48.96 Hyponatremia 3 47.92 Bartter Syndrome 2 46.56 Heart Rate Under Development 11 5.00 Cystic Fibrosis 6 5.00 Necrosis 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Antagonistic effects may have IFN gamma because short-circuit current measurements in the Ussing chamber of bronchial epithelial cells showed that it decreases CFTR dependent chloride secretion significantly, which was associated with a reduction in CFTR mRNA [49].

Negative_regulation (decreases) of Localization (secretion) of CFTR in epithelial cells

1) Confidence 0.34 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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