INT196692

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCNN1G)
SCNN1G (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 1 99.26 Very High Very High Very High
cytokine 21 78.96 Quite High
Inflammation 34 50.00 Quite Low
fibrosis 7 28.24 Quite Low
Inflammatory mediators 20 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
sodium channel 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 4 99.46 Very High Very High Very High
Heart Rate Under Development 15 64.80 Quite High
Coronary Artery Disease 1 63.40 Quite High
Colitis 3 62.84 Quite High
Pressure And Volume Under Development 13 62.40 Quite High
INFLAMMATION 56 50.00 Quite Low
Cystic Fibrosis 7 28.24 Quite Low
Cancer 6 6.48 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Diarrhoea 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone (250 nM, Sigma) was supplemented to stimulate ENaC expression.
Positive_regulation (stimulate) of Gene_expression (expression) of ENaC associated with dexamethasone
1) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2889873 Disease Relevance 0.19 Pain Relevance 0.05
In an ex vivo human colonic mucosa plus submucosa preparation of patients with ulcerative colitis aldosterone was unable to stimulate electrogenic sodium transport in the Ussing chamber or ENaC mRNA levels and protein expression [See figure 3].
Neg (unable) Positive_regulation (stimulate) of Gene_expression (expression) of ENaC associated with inflammatory bowel disease
2) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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