INT196695

Context Info Confidence 0.46 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0.27

protein complex (Prkaca, CFTR) cytoplasm (Prkaca, CFTR) plasma membrane (Prkaca, CFTR) transport (CFTR) mitochondrion (Prkaca) Golgi apparatus (Prkaca)

Prkaca (Mus musculus) CFTR (Homo sapiens)

Pain Link Frequency Relevance Heat substance P 3 84.96 Neuropeptide 1 79.12 Inflammation 34 75.24 cytokine 21 57.72 adenocard 5 56.48 Inflammatory mediators 20 5.00 bradykinin 10 5.00 sodium channel 9 5.00 fibrosis 6 5.00 agonist 5 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 4 75.80 Cryptosporidiosis 1 52.60 INFLAMMATION 56 50.00 Diarrhoea 8 5.20 Heart Rate Under Development 11 5.00 Disease 9 5.00 Cystic Fibrosis 6 5.00 Necrosis 5 5.00 Cancer 5 5.00 Pyelonephritis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This effect was mediated through cAMP activated protein kinase A (PKA), which activated CFTR.

PKA Positive_regulation (activated) of CFTR

1) Confidence 0.46 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.13 Pain Relevance 0.27

General Comments

This test has worked.