INT196697

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.01
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Srr) lyase activity (Srr) plasma membrane (Srr)
cellular amino acid metabolic process (Srr) cytoplasm (Srr)
Anatomy Link Frequency
lymphocytes 2
Nasal 2
respiratory tract epithelium 1
brain 1
spleen 1
Srr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 98.92 Very High Very High Very High
Inflammation 100 97.40 Very High Very High Very High
Glutamate 3 79.24 Quite High
Inflammatory response 9 70.80 Quite High
Neurotransmitter 2 39.60 Quite Low
Lasting pain 1 7.84 Low Low
imagery 14 5.00 Very Low Very Low Very Low
lidocaine 9 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 138 100.00 Very High Very High Very High
Respiratory Syncytial Virus 846 99.48 Very High Very High Very High
Infection 306 99.00 Very High Very High Very High
Pathologic Processes 1 98.64 Very High Very High Very High
Metastasis 35 98.24 Very High Very High Very High
INFLAMMATION 109 97.40 Very High Very High Very High
Measles 36 94.04 High High
Toxicity 3 91.44 High High
Congenital Anomalies 33 88.72 High High
Brain Tumor 1 88.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus it can be hypothesized that the anti-N IgA responses, triggered by nasal vaccination with N SRS, could limit RSV dissemination by interfering with its replication inside the cells from the respiratory tract epithelium.
N SRS Binding (vaccination) of in respiratory tract epithelium associated with respiratory syncytial virus
1) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.70 Pain Relevance 0.03
BALB/c adult mice were immunized intranasally with N SRS adjuvanted with the detoxified E. coli enterotoxin LT(R192G).
N SRS Binding (immunized) of
2) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262139 Disease Relevance 0.88 Pain Relevance 0.04
Finally, nasal immunization with N SRS generated strong local and systemic Ab responses, including a massive anti-N IgA Ab production in BAL.
N SRS Binding (immunization) of in nasal associated with immunization
3) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.87 Pain Relevance 0.06
We have indeed recorded a memory CD8+ T cell response in spleen following immunization with N SRS.
N SRS Binding (immunization) of in spleen associated with immunization
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.82 Pain Relevance 0.04
Nasal vaccination with N SRS protects against an RSV challenge
N SRS Binding (vaccination) of in Nasal associated with respiratory syncytial virus
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.40 Pain Relevance 0
Nasal vaccination with N SRS followed by RSV challenge results in the presence of activated CD4+ and CD8+ lymphocytes in airways
N SRS Binding (vaccination) of in lymphocytes associated with respiratory syncytial virus
6) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.32 Pain Relevance 0.08
Mucosal immunization with N SRS elicited strong local and systemic immunity characterized by high titers of IgG1, IgG2a and IgA anti-N antibodies, antigen-specific CD8+ T cells and IFN-?
N SRS Binding (immunization) of in T cells associated with immunization
7) Confidence 0.22 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2262139 Disease Relevance 0.82 Pain Relevance 0.05
N SRS immunization also induced antigen-specific IFN-?
N SRS Binding (immunization) of associated with immunization
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.82 Pain Relevance 0.03
One of the proteins that is more strongly associated with pineal SRs at night than at day is Bassoon.
SRs Binding (associated) of
9) Confidence 0.22 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2757586 Disease Relevance 0 Pain Relevance 0.11
Intra-nasal immunization with N SRS was specifically associated with the presence of CD4+CD69+ lymphocytes as early as 4 days and up to 10 days after virus infection (Fig. 6C), as compared with non vaccinated or LT(R192G) immunized mice where CD8+CD69+ lymphocytes were the predominant subset (Fig. 6C).
N SRS Binding (associated) of in lymphocytes associated with immunization and infection
10) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.64 Pain Relevance 0
Following this, the RTOG 95-08 trial was designed to determine the benefit of WBRT followed by SRS boost over WBRT alone in patients with 1–3 brain metastases ?
SRS Binding (boost) of in brain associated with metastasis
11) Confidence 0.12 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.91 Pain Relevance 0
Scavenger receptors (SRs) recognize endogenous molecules modified by pathological processes as well as components of diverse microorganisms.
SRs Binding (recognize) of associated with pathologic processes
12) Confidence 0.06 Published 2006 Journal BMC Microbiol Section Abstract Doc Link PMC1562429 Disease Relevance 0.46 Pain Relevance 0
It was during the founding meeting in Pescara 1994, Italy, when Marc Asher, a well recognized surgeon and SRS member, during a discussion on conservative management suddenly asked for opinions on the efficiency of bracing.
SRS Binding (recognized) of
13) Confidence 0.04 Published 2009 Journal Scoliosis Section Body Doc Link PMC2808165 Disease Relevance 0.36 Pain Relevance 0

General Comments

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