INT196710

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Context Info
Confidence 0.64
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.49
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VMO1)
Anatomy Link Frequency
knee 2
Quadriceps 1
adductors 1
VMO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Patellofemoral syndrome 203 99.74 Very High Very High Very High
Pain 451 99.28 Very High Very High Very High
antagonist 3 80.80 Quite High
Pain score 7 34.40 Quite Low
Neuropathic pain 2 19.68 Low Low
visual analogue scale 15 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Patellofemoral Pain Syndrome 219 99.74 Very High Very High Very High
Pain 442 99.28 Very High Very High Very High
Atrophy 3 96.88 Very High Very High Very High
Stress 20 84.16 Quite High
Congenital Anomalies 12 72.08 Quite High
Syndrome 19 68.76 Quite High
Cadaver 13 52.88 Quite High
Increased Venous Pressure Under Development 2 21.84 Low Low
Neuropathic Pain 2 19.68 Low Low
Knee Injuries 3 8.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hertel et al. [4] reported that both the VMO and VL are more activated in uniplanar knee extension when compared with knee extension/hip adduction or abduction.
Positive_regulation (activated) of VMO in knee
1) Confidence 0.64 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1562433 Disease Relevance 0 Pain Relevance 0.04
Since fibers of the VMO attach to the adductor magnus muscle, it has been hypothesized that activation of the VMO may be enhanced by combining active knee extension with volitional hip adduction [4,16,20].
Positive_regulation (activation) of VMO in knee
2) Confidence 0.55 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1562433 Disease Relevance 0.55 Pain Relevance 0.42
Boling et al [15] and Cowan et al [40] demonstrated a significant delay in VMO activation prior to physiotherapy, and subsequently, following successful treatment with pain reduction, a significantly earlier VMO activation was observed.
Positive_regulation (activation) of VMO associated with pain
3) Confidence 0.46 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.34 Pain Relevance 0.34
Boling et al [15] and Cowan et al [40] demonstrated a significant delay in VMO activation prior to physiotherapy, and subsequently, following successful treatment with pain reduction, a significantly earlier VMO activation was observed.
Positive_regulation (activation) of VMO associated with pain
4) Confidence 0.46 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.39 Pain Relevance 0.39
Quadriceps dysfunction in PFPS patients has been assessed in various ways including decreased magnitude of the electromyographic (EMG) activity of the quadriceps [5,6], diminished EMG activity of the VMO in relation to that of the VL [7-9], and the delayed onset of VMO activation in relation to the VL [10-12] caused by the inhibition of pain, effusion and atrophies[13].
Positive_regulation (activation) of VMO in Quadriceps associated with pain, atrophy and patellofemoral syndrome
5) Confidence 0.37 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1562433 Disease Relevance 0.59 Pain Relevance 0.50
If the reported results of these small studies are transferable they could indicate that although normal timing is variable, enhancing VMO onset times by reducing any delay in activation may be associated with pain relief.
Positive_regulation (enhancing) of VMO associated with pain
6) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.31 Pain Relevance 0.31
The results from four studies which measured onset timing of the VMO and VL during functional activities other than stair ascent and descent are presented in Figure 3.
Positive_regulation (timing) of VMO
7) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.30 Pain Relevance 0.30
There was an observable trend for a delay in the activation of VMO relative to that of VL in AKP patients.
Positive_regulation (activation) of VMO associated with pain
8) Confidence 0.31 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386790 Disease Relevance 0.10 Pain Relevance 0.10
A strong VMO with weak hip adductors results in the adductor magnus tendon being drawn to the patella; therefore, strong hip adductors serve as a stable origin for VMO contraction [73].
Positive_regulation (origin) of VMO in adductors
9) Confidence 0.26 Published 2008 Journal Dyn Med Section Body Doc Link PMC2443365 Disease Relevance 0.44 Pain Relevance 0.28
Historically, patellar taping has been advocated in treating PFPS patients to increase VMO activity and decrease VL activity [101].
Positive_regulation (increase) of VMO associated with patellofemoral syndrome
10) Confidence 0.24 Published 2008 Journal Dyn Med Section Body Doc Link PMC2443365 Disease Relevance 0.47 Pain Relevance 0.39

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