INT196732

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 120 99.28 Very High Very High Very High
long-term potentiation 12 60.48 Quite High
GABAergic 1 55.16 Quite High
depression 9 42.40 Quite Low
Action potential 5 10.56 Low Low
Central nervous system 2 6.96 Low Low
Glutamate 31 5.00 Very Low Very Low Very Low
gABA 12 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 9 42.40 Quite Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 8A and 8B shows that, over a large range of dissociation rates for calcium binding to AC5 or Ca4CaM binding to PDE1, the PKAc elevation and PP1 suppression in response to a dopamine signal is enhanced when dopamine is paired with calcium.
Localization (suppression) of PP1 associated with dopamine
1) Confidence 0.30 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21
As DARPP-32 phosphorylated by PKA inhibits protein phosphatase 1 (PP-1), reduction of PKA activity by GABABR would release PP-1 from the inhibition.
Localization (release) of PP-1
2) Confidence 0.20 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.10

General Comments

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