INT196733

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 18.25
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neurons 7
neuronal 1
nerves 1
hippocampus 1
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 102 99.04 Very High Very High Very High
Eae 60 98.08 Very High Very High Very High
Inflammation 74 97.96 Very High Very High Very High
Neuronal excitability 192 97.84 Very High Very High Very High
ischemia 18 93.76 High High
depression 143 92.64 High High
nMDA receptor 19 92.44 High High
antagonist 64 89.04 High High
Neurotransmitter 39 83.96 Quite High
medulla 22 81.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1036 99.96 Very High Very High Very High
Shock 112 99.72 Very High Very High Very High
Convulsion 750 99.56 Very High Very High Very High
Status Epilepticus 77 99.16 Very High Very High Very High
Disease 343 98.50 Very High Very High Very High
INFLAMMATION 90 98.32 Very High Very High Very High
Epilepsy 193 97.48 Very High Very High Very High
Malformations Of Cortical Development 22 97.44 Very High Very High Very High
Alzheimer's Dementia 12 97.00 Very High Very High Very High
Hyperplasia 4 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, transient overexpression of Cdk5-activating cofactor, p25, increases NMDAR-mediated plasticity and synaptic transmission [7], [15].
Gene_expression (overexpression) of Cdk5
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.64 Pain Relevance 0.15
Status epilepticus and electroconvulsive shock leads to the production of Cdk5-activating cofactor in the hippocampus
Gene_expression (production) of Cdk5 in hippocampus associated with shock, status epilepticus and hippocampus
2) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.63 Pain Relevance 0.11
CDK-5 along with its activators, p35 and p39, is predominantly expressed in post-mitotic neurons [3].
Gene_expression (expressed) of CDK-5 in neurons
3) Confidence 0.74 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.20 Pain Relevance 0.03
Namgung et al [5] reported a high expression of CDK-5 and p35 in regenerating nerves.
Gene_expression (expression) of CDK-5 in nerves
4) Confidence 0.74 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.21 Pain Relevance 0.04
A dichotomy may also exist for Cdk5/p25?
Gene_expression (exist) of Cdk5
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.17 Pain Relevance 0.17
A dichotomy may also exist for Cdk5/p25?
Gene_expression (/) of Cdk5
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.16 Pain Relevance 0.17
In summary, loss of Cdk5 for 2 months led to increased lethality, elevated seizure susceptibility, and electrographic evidence of seizure activity.


Gene_expression (loss) of Cdk5 associated with convulsion
7) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.96 Pain Relevance 0.08
There was also greater overall charge transfer in Cdk5 KO mice versus controls as measured by fEPSP areas (162.3±4.4 vs. 145.2±5.7% of baseline, respectively; Figure 3A, right).
Gene_expression (transfer) of Cdk5 associated with targeted disruption
8) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.59 Pain Relevance 0.17
Future studies examining Cdk5?
Spec (examining) Gene_expression (examining) of Cdk5
9) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.38 Pain Relevance 0.07
Conditional loss of Cdk5 leads to an enhancement in CA1 hippocampal post-tetanic potentiation
Gene_expression (leads) of Cdk5
10) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.79 Pain Relevance 0.17
Enhanced CDK-5 activity and expression of p35 are associated with differentiation of cultured neuronal cells as well as accelerated neurite outgrowth [4].
Gene_expression (expression) of CDK-5 in neuronal
11) Confidence 0.64 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.25 Pain Relevance 0.03
Abnormal expression and dysregulation of Cdk5 and its cofactors have been demonstrated in tissues from human cortical dysplasia [53] and hippocampal sclerosis [38], [46], [54].
Gene_expression (expression) of Cdk5 associated with malformations of cortical development and sclerosis
12) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.67 Pain Relevance 0.07
Although short-term loss of Cdk5 produced enhancements in plasticity and learning [7], it is possible that chronic loss of Cdk5 and the associated epileptiform activity leads to neurodegeneration and impaired synaptogenesis, learning, and structural plasticity [5], [16].


Gene_expression (produced) of Cdk5
13) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.43 Pain Relevance 0.15
Both conditional KO of Cdk5 [7] and transient overexpression of p25 [5] result in increased synaptic plasticity and learning.
Gene_expression (overexpression) of Cdk5 associated with targeted disruption
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 1.61 Pain Relevance 0.12
One of the newly identified actions of ASA is being the induction of p 35 synthesis and activation of CDK-5 [6].
Gene_expression (synthesis) of CDK-5
15) Confidence 0.56 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC1802865 Disease Relevance 0.44 Pain Relevance 0.17
, but also by cyclin-dependent protein kinase 5 (cdk5) [35].
Gene_expression (by) of cdk5
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.61 Pain Relevance 0.03
, but also by cyclin-dependent protein kinase 5 (cdk5) [35].
Gene_expression (by) of cyclin-dependent protein kinase 5
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.61 Pain Relevance 0.03
The percent of trigeminal neurons expressing Cdk5 was similar in WT and KI (61 ± 2%) cultured neurons (n = 3, p > 0.05).
Gene_expression (expressing) of Cdk5 in neurons
18) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
In keeping with the enhanced functional responses of KI neurons, we compared the expression of Cdk5 in WT and KI neurons.
Gene_expression (expression) of Cdk5 in neurons
19) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
Western blotting of membrane fractions indicated a significant overall decrease of Cdk5 expression in lysates from KI ganglia (0.7 ± 0.025 fold change versus WT; n = 4, p = 0.04; Fig. 6A) together with lower P2X3/Cdk5 co-immunoprecipitation (0.8 ± 0.02 fold change in KI versus WT; n = 3, p = 0.03; Fig. 6B) despite analogous levels of total Cdk5 expression (see Fig. 6A), suggesting a different compartmentalisation of this molecules in KI neurons.
Gene_expression (expression) of Cdk5 in neurons
20) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0

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