INT196734

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adcy5) lyase activity (Adcy5) plasma membrane (Adcy5)
cilium (Adcy5)
Anatomy Link Frequency
striatum 1
Adcy5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 476 94.80 High High
Glutamate 124 83.32 Quite High
imagery 12 18.08 Low Low
long-term potentiation 32 5.00 Very Low Very Low Very Low
projection neuron 16 5.00 Very Low Very Low Very Low
Action potential 16 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
dopamine receptor 8 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binds to and activates adenylate cyclase type V (AC5) in the striatum [70,71,87], which produces cyclic AMP (cAMP).
Positive_regulation (activates) of AC5 in striatum
1) Confidence 0.35 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.24
In the model, calcium is allowed to bind to the inactive AC5, which then can be activated by Golf?
Positive_regulation (activated) of AC5
2) Confidence 0.31 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.05
Opening up both reactions in the loop actually transforms the effect of calcium on PKAc into inhibition (due to inhibition of AC5 and activation of PDE1).
Positive_regulation (activation) of AC5
3) Confidence 0.24 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.11
That less PKAc becomes activated in the presence of increased levels of calcium may be expected because of the calcium-dependent AC5 inhibition as well as calcium-dependent PDE1 activation.
Positive_regulation (activation) of AC5
4) Confidence 0.21 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.35

General Comments

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