INT196736

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 2.01
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
neurons 6
striatum 4
output neurons 1
neuronal 1
brain 1
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 28 99.98 Very High Very High Very High
Dopamine 909 99.80 Very High Very High Very High
sSRI 91 99.34 Very High Very High Very High
fluoxetine 2 99.16 Very High Very High Very High
dopamine receptor 64 99.00 Very High Very High Very High
GABAergic 91 97.36 Very High Very High Very High
Ventral tegmentum 86 95.16 Very High Very High Very High
Neurotransmitter 26 94.56 High High
Glutamate 129 90.56 High High
amygdala 13 90.08 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 261 99.88 Very High Very High Very High
Urological Neuroanatomy 8 73.68 Quite High
Sprains And Strains 63 73.16 Quite High
Leukemia 2 70.32 Quite High
Depression 56 68.80 Quite High
Manic Depressive Disorder 17 51.60 Quite High
Attention Deficit Hyperactivity Disorder 36 45.28 Quite Low
Neurological Disease 1 44.56 Quite Low
Anxiety Disorder 19 35.36 Quite Low
Stress 15 33.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although not all DARPP-32 expressing neurons contain D1-like dopamine receptors, DARPP-32 is present in practically all D1-like receptor-containing neurons [56], and is generally regarded as a useful marker to determine where increased D1-like receptor activity is occurring within the brain.
Gene_expression (expressing) of DARPP-32 in brain associated with dopamine receptor
1) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
The differences seen in c-Fos expression compared to pTH and pDARPP-32 expression also indicate that dopamine may not be the only player influencing neglect.
Gene_expression (expression) of pDARPP-32 associated with dopamine
2) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.07 Pain Relevance 0.64
Neglectful females show region specific differences in c-Fos, phosphorylated tyrosine hydroxylase (pTH), and phosphorylated DARPP-32 (pDARPP-32) expression compared to their nurturing counterparts.
Gene_expression (expression) of DARPP-32
3) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
Neglectful females show region specific differences in c-Fos, phosphorylated tyrosine hydroxylase (pTH), and phosphorylated DARPP-32 (pDARPP-32) expression compared to their nurturing counterparts.
Gene_expression (expression) of pDARPP-32
4) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
c-Fos, pTH, TH, and pDARPP-32 expression in neglectful MaD1 mice
Gene_expression (expression) of pDARPP-32
5) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.04
For pTH, TH and pDARPP-32, sections were washed three times in 0.1 M tris-buffered saline (TBS, pH 7.4) and then in TBS containing 0.1% sodium borohydride for 15 minutes.
Gene_expression (washed) of pDARPP-32
6) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.05
Analysis of c-Fos, pTH, TH, and pDARPP-32 immunoreactivity
Gene_expression (Analysis) of pDARPP-32
7) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.03
We have previously reported that EGFP is detected only in DARPP-32-positive neurons in the striatum of drd1a-EGFP mice, while in drd2-EGFP mice it is detected in DARPP-32-positive and in a few DARPP-32-negative and ChAT-positive neurons [13].
Gene_expression (detected) of DARPP-32-negative in striatum
8) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.28 Pain Relevance 0
Finally, the percentages of neurons for each category were determined among DARPP-32-positive neurons.


Spec (determined) Gene_expression (neurons) of DARPP-32-positive in neurons
9) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.10 Pain Relevance 0
We have previously reported that EGFP is detected only in DARPP-32-positive neurons in the striatum of drd1a-EGFP mice, while in drd2-EGFP mice it is detected in DARPP-32-positive and in a few DARPP-32-negative and ChAT-positive neurons [13].
Gene_expression (detected) of DARPP-32-positive in striatum
10) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.27 Pain Relevance 0
The same quantification was done for DARPP-32-immunoreactive neurons and the percentage of TO-PRO-3-labeled cells that were DARPP-32-positive neurons was calculated.
Gene_expression (neurons) of DARPP-32-positive in neurons
11) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.07 Pain Relevance 0
We have previously reported that EGFP is detected only in DARPP-32-positive neurons in the striatum of drd1a-EGFP mice, while in drd2-EGFP mice it is detected in DARPP-32-positive and in a few DARPP-32-negative and ChAT-positive neurons [13].
Gene_expression (neurons) of DARPP-32-positive in striatum
12) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.22 Pain Relevance 0
The same quantification was done for DARPP-32-immunoreactive neurons and the percentage of TO-PRO-3-labeled cells that were DARPP-32-positive neurons was calculated.
Gene_expression (neurons) of DARPP-32-immunoreactive in neurons
13) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.07 Pain Relevance 0
We were simply unable to find any DARPP-32-immunoreactive neuron which lacked EGFP fluorescence.
Gene_expression (neuron) of DARPP-32-immunoreactive in neuron
14) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.29 Pain Relevance 0.06
Transgenic mice with the same promoters expressing tagged DARPP-32 [18] or Cre [19] in the two populations allow further study of each cell population, and the use of other promoters [20] or different fluorescent reporters [21] provides additional powerful tools.
Gene_expression (expressing) of DARPP-32 associated with targeted disruption
15) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.26 Pain Relevance 0.31
Importantly, the expression of DARPP32 driven Cre in this model does not commence until 4-5 weeks after birth [12], ensuring a lack of potential developmental compensation.


Gene_expression (expression) of DARPP32
16) Confidence 0.34 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.21
Interestingly, these cells, when dissected from E18.5 LGE and MGE SVZ, expressed MAP2 as well as striatal markers (DARPP32, calbindin, and EBF), suggesting that Arx mutant SVZ cells of the LGE are capable of differentiation, and that the maturation defects observed in mutant mice may result from non-adapted local factors in the SVZ.
Gene_expression (expressed) of DARPP32
17) Confidence 0.31 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.21
A key signalling molecule is the phosphoprotein DARPP-32, highly expressed in striatal medium spiny neurons.
Gene_expression (expressed) of DARPP-32 in neurons
18) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Abstract Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21
These cells were also negative for various striatal markers such as Ebf1 or enkephalin mRNAs and calbindin, DARPP32 and dopamine 2 receptor, suggesting that they are unable to differentiate (Colombo et al., 2007).
Gene_expression (mRNAs) of DARPP32 associated with dopamine and enkephalin
19) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0 Pain Relevance 0.18
DARPP-32 is a dual-function protein selectively expressed in all MSNs and is therefore viewed as a critical integrator of many signaling events occurring in these neurons (Svenningsson et al., 2004).
Gene_expression (expressed) of DARPP-32 in neurons
20) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.08 Pain Relevance 0.20

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