INT196739

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 0
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 99.28 Very High Very High Very High
sodium channel 37 96.32 Very High Very High Very High
Dopamine 128 93.56 High High
Glutamate receptor 11 87.24 High High
antidepressant 39 61.60 Quite High
Spinal cord 13 61.52 Quite High
Neurotransmitter 22 56.08 Quite High
GABAergic 32 50.00 Quite Low
Calcium channel 9 47.44 Quite Low
long-term potentiation 23 45.04 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 16 25.60 Quite Low
Depression 75 5.00 Very Low Very Low Very Low
Affective Disorder 12 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, DARRP-32, whose involvement in potentially affecting SSRI response was discussed above, is a regulator of PP1 (Svenningsson et al 2002).
Regulation (regulator) of PP1 associated with ssri
1) Confidence 0.19 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.18
M produced a change in the basal level of PKAc, phosphoThr34, and PP1, but produced very little change in the ratio PKAc:PP1.
Regulation (change) of PP1
2) Confidence 0.18 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.25
To elucidate the role of PDE1 inhibition by CaMKII, we analyzed how the CaMKII activity affects the PP-1 activity through PDE1 phosphorylation.
Spec (analyzed) Regulation (affects) of PP-1
3) Confidence 0.14 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The increase of Ca2+/Calmodulin additionally activates calcineurin that shifts the equilibrium towards the unphosphorylated form of DARPP-32, which has no effect on PP-1.
Neg (no) Regulation (effect) of PP-1
4) Confidence 0.10 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0
The rate of PDE1 phosphorylation determined the working range within which a change of the CaMKII activity effectively influenced the PP-1 activity.
Regulation (influenced) of PP-1
5) Confidence 0.09 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The limited influence of calcineurin activity on the Ca2+ threshold for RP induction is presumably attributable to its shorter-lasting effect on PP-1 activity and the lower affinity for Ca2+/CaM compared with PDE1.
Regulation (effect) of PP-1
6) Confidence 0.09 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Both the tonic reduction in INa peak amplitude and the occlusion of rapid T4 effects under conditions of PP1 blockade support the view that PP1 activity modulates RB INa amplitudes.


Regulation (modulates) of PP1
7) Confidence 0.04 Published 2009 Journal Neural Dev Section Body Doc Link PMC2704202 Disease Relevance 0 Pain Relevance 0.20

General Comments

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