INT196741

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ppp1cc) carbohydrate metabolic process (Ppp1cc) protein complex (Ppp1cc)
cytoplasm (Ppp1cc) chromosome (Ppp1cc) nucleolus (Ppp1cc)
Ppp1cc (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 238 100.00 Very High Very High Very High
depression 39 100.00 Very High Very High Very High
long-term potentiation 71 99.96 Very High Very High Very High
Glutamate 63 99.38 Very High Very High Very High
Hippocampus 12 74.96 Quite High
gABA 2 68.00 Quite High
Calcium channel 4 64.16 Quite High
Action potential 9 10.56 Low Low
nMDA receptor 19 5.00 Very Low Very Low Very Low
projection neuron 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 39 100.00 Very High Very High Very High
Targeted Disruption 90 85.52 High High
Anxiety Disorder 28 50.00 Quite Low
Shock 7 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypesthesia 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the inhibition of PP1 abolished LTD and activated LTP [15], [16], [37], [38].
Positive_regulation (activated) of Negative_regulation (inhibition) of PP1 associated with depression and long-term potentiation
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.42 Pain Relevance 0.31
More significantly, combined dopamine and glutamate stimulation produces a larger activation of PKA and inhibition of PP1 than dopamine alone (Figure 5).
Positive_regulation (activation) of Negative_regulation (inhibition) of PP1 associated with glutamate and dopamine
2) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.24
Figure 8A and 8B shows that, over a large range of dissociation rates for calcium binding to AC5 or Ca4CaM binding to PDE1, the PKAc elevation and PP1 suppression in response to a dopamine signal is enhanced when dopamine is paired with calcium.
Positive_regulation (enhanced) of Negative_regulation (suppression) of PP1 associated with dopamine
3) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox