INT196742

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.05
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 377 99.48 Very High Very High Very High
Calcium channel 6 84.44 Quite High
Glutamate 93 68.56 Quite High
nMDA receptor 6 24.88 Low Low
agonist 3 19.72 Low Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
Substantia nigra 12 5.00 Very Low Very Low Very Low
projection neuron 12 5.00 Very Low Very Low Very Low
Action potential 12 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 54.40 Quite High
Aging 3 12.64 Low Low
Parkinson's Disease 18 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK phosphorylation was diminished in a-Syn cells compared with GFP-transfected MN9D controls, and furthermore, inhibition of PP2A increased ERK phosphorylation in our cells (data not shown), suggesting that only a-Syn interacting proteins were affected by a-Syn-mediated PP2A activation.
Positive_regulation (mediated) of Positive_regulation (activation) of PP2A
1) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.05 Pain Relevance 0.04
Steady-state calcium produces a large increase in PP2B, dephosphorylating phosphoThr34; in contrast, large, transient calcium elevations produce an increase in PP2A activation and consequent disinhibition of free PKAc due to phosphoThr75 dephosphorylation.
Positive_regulation (increase) of Positive_regulation (activation) of PP2A
2) Confidence 0.44 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.03
The calcium pulse given simultaneously with the dopamine input also significantly enhances the decrease in phosphoThr75 (Figure 5E) due to the additional calcium-dependent activation of PP2A, which further elevates PP2A activity.
Positive_regulation (enhances) of Positive_regulation (activation) of PP2A associated with dopamine
3) Confidence 0.44 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.43
In contrast, the dephosphorylation of Thr75 is dependent on calcium activation of PP2A.
Positive_regulation (dependent) of Positive_regulation (activation) of PP2A
4) Confidence 0.30 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.18

General Comments

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