INT196753

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.52
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 248 93.04 High High
antagonist 19 86.64 High High
Eae 7 85.28 High High
nMDA receptor 61 81.60 Quite High
Glutamate 84 44.88 Quite Low
cytokine 2 9.96 Low Low
Inflammation 9 9.60 Low Low
Neurotransmitter 8 8.20 Low Low
cocaine 31 5.00 Very Low Very Low Very Low
Morphine 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 13 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 2 89.96 High High
Disease 43 86.32 High High
Toxicity 7 56.36 Quite High
Hypoxia 6 28.00 Quite Low
Tauopathy 1 18.16 Low Low
INFLAMMATION 6 9.60 Low Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Removing the phosphorylation of PP2A by PKAc should decrease the modulation of phosphoThr75, and reduce the disinhibition of PKAc.
Negative_regulation (reduce) of Phosphorylation (phosphorylation) of PP2A
1) Confidence 0.37 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21
Removing the phosphorylation of PP2A by PKAc should decrease the modulation of phosphoThr75, and reduce the disinhibition of PKAc.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of PP2A
2) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.21
Memantine (10 ┬ÁM) inhibited this abnormal phosphorylation of tau and cell death and prevented the I(2)(PP2A)-induced inhibition of PP2A activity with no effect on basal activity [47].
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of PP2A associated with death
3) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.52 Pain Relevance 0.27

General Comments

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