INT196754

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 0.42
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 91 95.92 Very High Very High Very High
Dopamine 440 95.52 Very High Very High Very High
Glutamate receptor 2 84.60 Quite High
nMDA receptor 9 72.64 Quite High
Potency 4 72.40 Quite High
Neurotransmitter 23 62.04 Quite High
Glutamate 93 60.64 Quite High
antidepressant 39 58.96 Quite High
Catecholamine 24 53.08 Quite High
Calcium channel 12 49.68 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 72 71.04 Quite High
Targeted Disruption 42 65.12 Quite High
Aging 12 57.04 Quite High
Neurodegenerative Disease 8 53.60 Quite High
Toxicity 8 34.56 Quite Low
Depression 40 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Affective Disorder 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This regulation further appears to be selective, as another major PP2A target, the protein kinase B/Akt (58, 59), that does not bind a-Syn retains normal levels of phosphorylation in our a-Syn-overexpressing cells (44), suggesting the existence of a microdomain(s) where a-Syn localizes with PP2A and dopamine regulatory proteins (9, 31).


PP2A Neg (not) Binding (bind) of associated with dopamine
1) Confidence 0.37 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.07 Pain Relevance 0.05
, a kinase that binds both PP2A (84) and a-Syn (26).
PP2A Binding (binds) of
2) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.25 Pain Relevance 0.11
g of protein), and both phosphorylated and unphosphorylated a-Syn enhanced PP2A activity; however, unphosphorylated a-Syn activated PP2A more (1421 ± 73 pmol/min/?
PP2A Binding (activity) of
3) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.04
In vivo, a-Syn may also bind particular PP2A B subunits that contribute to TH dephosphorylation (83).
PP2A Binding (bind) of
4) Confidence 0.32 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.11 Pain Relevance 0.14
As more PKAc is formed, much of it is bound to PP2A in the enzyme-substrate complex, as well as to phosphoThr75 in the inhibitory complex (Figure S1A).
PP2A Binding (bound) of
5) Confidence 0.31 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.18
Thus, binding of calcium to PP2A has two important effects.
PP2A Binding (binding) of
6) Confidence 0.31 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.11
The disinhibition of PKA when phosphoThr75 is dephosphorylated has been suggested to be an important part of the potentiating effect of DARPP-32 on PKA activity [65]: PKA enhances PP2A activity via phosphorylation; then PP2Ap dephosphorylates phosphoThr75 at an accelerated rate and the decrease in phosphoThr75 leads to more active PKA.
PP2A Binding (activity) of
7) Confidence 0.24 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.11
A second phosphatase, PP2A, exists as a heterotrimer, with a catalytic, regulatory, and scaffolding subunit.
PP2A Binding (heterotrimer) of
8) Confidence 0.07 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0 Pain Relevance 0.17

General Comments

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