INT196759

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 119 91.28 High High
alcohol 24 53.72 Quite High
ischemia 6 18.64 Low Low
Glutamate 31 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 86.08 High High
Coronary Heart Disease 8 50.00 Quite Low
Apoptosis 4 43.68 Quite Low
Stress 8 38.20 Quite Low
Neurodegenerative Disease 2 22.00 Low Low
Diabetes Mellitus 4 19.68 Low Low
Cv Unclassified Under Development 6 18.64 Low Low
Impaired Glucose Tolerance 20 5.00 Very Low Very Low Very Low
Toxicity 14 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Observation from our study also depicted downregulation of PP2A (PP2AA in particular without change in PP2AB) following acute ethanol challenge, the effect of which was augmented by the ADH transgene.
Negative_regulation (depicted) of Negative_regulation (downregulation) of PP2A
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.03
Observation from our study also depicted downregulation of PP2A (PP2AA in particular without change in PP2AB) following acute ethanol challenge, the effect of which was augmented by the ADH transgene.
Negative_regulation (depicted) of Negative_regulation (downregulation) of PP2AA
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.03
Opening reaction (i) eliminates the reduction of PKAc-PP2A by calcium, and opening reaction (iii) eliminates the reduction of PKAc-phosphoThr75 by calcium.
Negative_regulation (eliminates) of Negative_regulation (reduction) of PKAc-PP2A
3) Confidence 0.27 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.14

General Comments

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