INT196761

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 2 84.44 Quite High
Dopamine 139 76.64 Quite High
agonist 1 19.72 Low Low
Glutamate 31 5.00 Very Low Very Low Very Low
Substantia nigra 10 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 54.40 Quite High
Aging 3 12.64 Low Low
Parkinson's Disease 18 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK phosphorylation was diminished in a-Syn cells compared with GFP-transfected MN9D controls, and furthermore, inhibition of PP2A increased ERK phosphorylation in our cells (data not shown), suggesting that only a-Syn interacting proteins were affected by a-Syn-mediated PP2A activation.
Regulation (affected) of Positive_regulation (activation) of PP2A
1) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.05 Pain Relevance 0.04
In contrast, the dephosphorylation of Thr75 is dependent on calcium activation of PP2A.
Regulation (dependent) of Positive_regulation (activation) of PP2A
2) Confidence 0.29 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.18

General Comments

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