INT196762

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.49
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adcy5) lyase activity (Adcy5) plasma membrane (Adcy5)
cilium (Adcy5)
Adcy5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 476 94.92 High High
Glutamate 124 83.32 Quite High
Neurotransmitter 14 66.68 Quite High
Action potential 16 19.84 Low Low
long-term potentiation 32 5.00 Very Low Very Low Very Low
projection neuron 16 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Calcium channel 8 5.00 Very Low Very Low Very Low
dopamine receptor 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 80 98.60 Very High Very High Very High
Stress 2 97.20 Very High Very High Very High
Disease 16 96.44 Very High Very High Very High
Aging 60 95.48 Very High Very High Very High
Obesity 42 62.88 Quite High
Weight Gain 2 7.44 Low Low
Hyperinsulinism 10 6.40 Low Low
Body Weight 30 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Fatty Liver 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, it is of interest that disruption of the AC isoform type 5 adenylyl cyclase (AC5) in mice was reported to increase lifespan and resistance to cardiac stress in mice [5].
Negative_regulation (disruption) of AC5 associated with stress and lifespan
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 0.75 Pain Relevance 0.03
In this regard, it is of interest that disruption of the AC isoform type 5 adenylyl cyclase (AC5) in mice was reported to increase lifespan and resistance to cardiac stress in mice [5].
Negative_regulation (disruption) of isoform type 5 adenylyl cyclase associated with stress and lifespan
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2693670 Disease Relevance 0.75 Pain Relevance 0.03
Opening up both reactions in the loop actually transforms the effect of calcium on PKAc into inhibition (due to inhibition of AC5 and activation of PDE1).
Negative_regulation (inhibition) of AC5
3) Confidence 0.22 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.11
Calcium causes a 50% reduction in the activity of AC5 [91], though it is not known whether calcium binds to AC5 before or after binding to Golf?.
Negative_regulation (reduction) of AC5
4) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.08
That less PKAc becomes activated in the presence of increased levels of calcium may be expected because of the calcium-dependent AC5 inhibition as well as calcium-dependent PDE1 activation.
Negative_regulation (inhibition) of AC5
5) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.35
This is partly due to calcium-dependent inhibition of AC5 and calcium-dependent activation of PDE1, but also because now the PKA–PP2A–phosphoThr75 loop instead works as a sink for PKAc.
Negative_regulation (inhibition) of AC5
6) Confidence 0.19 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.19

General Comments

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