INT196765

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.05
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 199 97.88 Very High Very High Very High
Eae 14 92.04 High High
nMDA receptor 116 82.24 Quite High
antagonist 38 70.96 Quite High
Action potential 8 44.68 Quite Low
cytokine 4 16.72 Low Low
Inflammation 18 16.36 Low Low
Glutamate 75 15.36 Low Low
Neurotransmitter 10 14.96 Low Low
cocaine 62 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 4 96.72 Very High Very High Very High
Disease 89 93.08 High High
Death 26 86.96 High High
Toxicity 20 63.12 Quite High
Hypoxia 12 34.76 Quite Low
INFLAMMATION 12 16.36 Low Low
Necrosis 2 8.48 Low Low
Cancer 16 8.12 Low Low
Parkinson's Disease 66 5.00 Very Low Very Low Very Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To verify this by non-pharmacological means, we transiently overexpressed the wild type PP2A catalytic domain (PP2A-WT) (52) in MN9D cells and then measured TH-Ser(P)-19 in comparison to mock-transfected MN9D cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PP2A
1) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Overexpression of PP2A-WT did not alter total TH levels; however, TH-Ser(P)-19 levels were measurably reduced (Fig. 2C).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PP2A
2) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
To verify this by non-pharmacological means, we transiently overexpressed the wild type PP2A catalytic domain (PP2A-WT) (52) in MN9D cells and then measured TH-Ser(P)-19 in comparison to mock-transfected MN9D cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PP2A
3) Confidence 0.44 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
The main findings from these simulations suggest that the presence of the PKA–PP2A–phosphoThr75 loop causes increased formation of free PKAc as well as phosphoThr34 if a dopamine input is paired with a transient calcium elevation.
Positive_regulation (increased) of Gene_expression (presence) of PP2A associated with dopamine
4) Confidence 0.32 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.07
Transient transfection of PC12 cells with inhibitor-2 of PP2A (I(2)(PP2A)) also causes abnormal hyperphosphorylation of tau at Ser396/ Ser404 and Ser262/Ser356.
Positive_regulation (transfection) of Gene_expression (transfection) of PP2A
5) Confidence 0.04 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.53 Pain Relevance 0.26
Transient transfection of PC12 cells with inhibitor-2 of PP2A (I(2)(PP2A)) also causes abnormal hyperphosphorylation of tau at Ser396/ Ser404 and Ser262/Ser356.
Positive_regulation (transfection) of Gene_expression (transfection) of PP2A
6) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.52 Pain Relevance 0.26

General Comments

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