INT196773

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1a) nucleus (Pde1a) cytoplasm (Pde1a)
Pde1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 119 82.96 Quite High
Glutamate 31 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opening up both reactions in the loop actually transforms the effect of calcium on PKAc into inhibition (due to inhibition of AC5 and activation of PDE1).
Negative_regulation (inhibition) of Positive_regulation (activation) of PDE1
1) Confidence 0.01 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.11

General Comments

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