INT196790

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.60
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neuronal 2
spikes 1
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 6 99.20 Very High Very High Very High
ischemia 24 89.64 High High
Dopamine 119 89.60 High High
hyperexcitability 6 80.48 Quite High
antagonist 12 74.56 Quite High
Neuronal excitability 34 73.04 Quite High
Inflammation 4 67.44 Quite High
long-term potentiation 36 64.08 Quite High
Glutamate receptor 7 50.56 Quite High
Glutamate 32 49.32 Quite Low
Disease Link Frequency Relevance Heat
Disease 4 100.00 Very High Very High Very High
Targeted Disruption 302 98.88 Very High Very High Very High
Death 34 96.04 Very High Very High Very High
Convulsion 136 95.80 Very High Very High Very High
Cv General 4 Under Development 5 89.64 High High
Neurodegenerative Disease 3 83.60 Quite High
Apoptosis 4 82.00 Quite High
Drug Induced Neurotoxicity 2 79.64 Quite High
Cognitive Disorder 6 69.40 Quite High
Stroke 27 67.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of Cdk5 lowered the threshold for population spikes and this could not be rescued by substantial reduction (>50%) in Na+ channel availability [34].
Localization (Loss) of Cdk5 in spikes
1) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.49 Pain Relevance 0.15
Future studies on Cdk5, calpain, p25, and NR2B may better our understanding of the divergent roles for Cdk5 in neuronal physiology and disease.
Localization (disease) of Cdk5 in neuronal associated with disease
2) Confidence 0.74 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.90 Pain Relevance 0.11
For instance, the cyclin-dependent kinase 5 (Cdk5) activator, p35, is cleaved to p25 by calpain [3,4], and the generated p25 hyperactivates Cdk5, possibly leading to neurodegeneration.
Localization (cleaved) of Cdk5
3) Confidence 0.62 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.16 Pain Relevance 0.06
For instance, the cyclin-dependent kinase 5 (Cdk5) activator, p35, is cleaved to p25 by calpain [3,4], and the generated p25 hyperactivates Cdk5, possibly leading to neurodegeneration.
Localization (cleaved) of cyclin-dependent kinase 5
4) Confidence 0.62 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.16 Pain Relevance 0.06
The p25 fragment triggers CDK5 hyperactivation and translocation of the p25/CDK5 complex to the cytoplasm where it hyperphosphorylates a number of substrates, leading to neuronal death [13].
Localization (translocation) of CDK5 in neuronal associated with death
5) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.90 Pain Relevance 0.17
The total concentration of PKA, PP2A, PP2B, and cdk5 were set to 10% of control values, and the dynamics of the PKA system were accelerated, i.e., the rate constants for all reactions involving PKA were increased 100-fold.
Localization (concentration) of cdk5
6) Confidence 0.33 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.10

General Comments

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