INT196799

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkaca, Trh) nucleus (Prkaca, Trh) cytoplasm (Prkaca, Trh)
mitochondrion (Prkaca) extracellular region (Trh) Golgi apparatus (Prkaca)
Prkaca (Mus musculus)
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 31 97.72 Very High Very High Very High
Dopamine 119 97.40 Very High Very High Very High
long-term potentiation 8 95.68 Very High Very High Very High
projection neuron 4 70.48 Quite High
imagery 3 24.56 Low Low
Action potential 4 19.52 Low Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors.
PKA Positive_regulation (activation) of Phosphorylation (phosphorylation) of Thr34 associated with glutamate and long-term potentiation
1) Confidence 0.02 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.74

General Comments

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