INT196834

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Prkaca, Ppp1r1b) nucleus (Prkaca, Ppp1r1b) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) intracellular (Ppp1r1b) protein complex (Prkaca)
Prkaca (Mus musculus)
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 12 98.84 Very High Very High Very High
Dopamine 120 97.40 Very High Very High Very High
Glutamate 31 97.36 Very High Very High Very High
Central nervous system 2 86.28 High High
projection neuron 4 69.76 Quite High
interneuron 1 65.92 Quite High
imagery 8 23.84 Low Low
Action potential 5 18.80 Low Low
gABA 12 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 49.68 Quite Low
Depression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTP-inducing high-frequency stimulation has been reported to cause sustained DARPP-32 phosphorylation by PKA in a manner dependent on CaMKII in hippocampal slices (Atkins et al, 2005).
PKA Positive_regulation (cause) of Phosphorylation (phosphorylation) of DARPP-32 associated with long-term potentiation
1) Confidence 0.15 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.13
Thus, model simulations suggest that PKA activation, phosphorylation of DARPP-32 at Thr34, and subsequent PP1 inhibition, produced by conjunctive glutamate and D1 receptor stimulation, can produce LTP by increased phosphorylation of AMPA receptors.
PKA Positive_regulation (activation) of Phosphorylation (phosphorylation) of DARPP-32 associated with glutamate and long-term potentiation
2) Confidence 0.11 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.74

General Comments

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