INT19685

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 0.83
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Sult2a1) aging (Sult2a1) cytoplasm (Sult2a1)
Anatomy Link Frequency
ileum 1
enterocytes 1
jejunum 1
nerves 1
proximal 1
Sult2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 18 99.60 Very High Very High Very High
Enkephalin 12 99.50 Very High Very High Very High
nud 6 99.04 Very High Very High Very High
lidocaine 4 97.68 Very High Very High Very High
Acupuncture 8 96.92 Very High Very High Very High
withdrawal 1 81.60 Quite High
Pain threshold 3 76.88 Quite High
tetrodotoxin 2 56.32 Quite High
qutenza 3 53.76 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 100.00 Very High Very High Very High
Dyspepsia 6 99.04 Very High Very High Very High
Pain 3 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, neuropeptide Y but not methionine-enkephalin significantly inhibited STa-induced jejunal fluid secretion although neuropeptide Y was without effect on basal fluid transport.
Localization (secretion) of STa associated with neuropeptide and enkephalin
1) Confidence 0.70 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.33
The myenteric plexus, however, is a site of 5-HT synthesis in the gut, and the plexus mediates electrogenic ion secretion activated by luminal enterotoxin STa and taurocholate.
Localization (secretion) of STa in gut
2) Confidence 0.68 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597113 Disease Relevance 0 Pain Relevance 0.11
However, ST25 which is a key acupoint for patients with IBS has not been reported in these experiments.
Neg (not) Localization (reported) of ST25
3) Confidence 0.64 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 19387829 Disease Relevance 0.63 Pain Relevance 0.75
Hexamethonium (10 mg/kg intravenously) significantly diminished the effects of STa on PD, whereas only a small inhibition of the STa-induced alkaline secretion was observed.
Localization (secretion) of STa-induced
4) Confidence 0.61 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2406887 Disease Relevance 0 Pain Relevance 0.10
The effects of the heat-stable enterotoxin of Escherichia coli (STa) on intestinal alkaline secretion and transepithelial electric potential difference (PD) were investigated in vivo in denervated segments of rat jejunum, ileum, and proximal colon.
Localization (secretion) of STa in proximal
5) Confidence 0.61 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2406887 Disease Relevance 0 Pain Relevance 0
To test the possible involvement of the enteric nervous system in the STa-stimulated alkaline secretion and potential difference, the mesenteric nerves were electrically stimulated or neuropeptide Y or methionine-enkephalin was infused intravenously.
Localization (secretion) of STa in nerves associated with neuropeptide and enkephalin
6) Confidence 0.61 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.28
Furthermore, alkaline secretion may not contribute to the increase in potential difference caused by STa Amiloride (10(-4) or 10(-3) M) had no effect on the STa-stimulated alkaline secretion, implying that some cellular mechanism other than an inhibition of Na+/H+ exchanger explains the observed response.
Localization (secretion) of STa
7) Confidence 0.61 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.27
None of these interventions inhibited to any large extent the STa-stimulated alkaline secretion, whereas a greater suppression was noted on the concomitantly increased potential difference.
Localization (secretion) of STa
8) Confidence 0.61 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.32
It is concluded that the enteric nervous reflex(es) which are of significant importance in explaining STa-evoked fluid secretion plays a minor role in controlling alkaline secretion.
Localization (secretion) of STa
9) Confidence 0.61 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.30
Similarly, acetazolamide had no effect on the STa-stimulated alkaline secretion or potential difference, suggesting that the secreted alkaline is of extracellular origin rather than from the cellular metabolism in the enterocytes.
Localization (secretion) of STa in enterocytes
10) Confidence 0.61 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 2082716 Disease Relevance 0 Pain Relevance 0.24
The effects of the heat-stable enterotoxin of Escherichia coli (STa) on intestinal alkaline secretion and transepithelial electric potential difference (PD) were investigated in vivo in denervated segments of rat jejunum, ileum, and proximal colon.
Localization (secretion) of STa in jejunum
11) Confidence 0.21 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2406887 Disease Relevance 0 Pain Relevance 0
The effects of the heat-stable enterotoxin of Escherichia coli (STa) on intestinal alkaline secretion and transepithelial electric potential difference (PD) were investigated in vivo in denervated segments of rat jejunum, ileum, and proximal colon.
Localization (secretion) of STa in ileum
12) Confidence 0.21 Published 1990 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 2406887 Disease Relevance 0 Pain Relevance 0

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