INT196863

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.87
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry4) plasma membrane (P2ry4) signal transducer activity (P2ry4)
Anatomy Link Frequency
P19 1
cardiovascular system 1
astrocytes 1
placenta 1
P2ry4 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 44 99.22 Very High Very High Very High
antagonist 60 95.48 Very High Very High Very High
Pain 15 90.12 High High
Kinase C 12 88.00 High High
nMDA receptor 7 85.68 High High
ASIC 3 82.24 Quite High
Glutamate 24 78.04 Quite High
Action potential 6 72.64 Quite High
imagery 24 65.92 Quite High
Potency 3 64.24 Quite High
Disease Link Frequency Relevance Heat
Pre-eclampsia 1 99.20 Very High Very High Very High
Stress 19 95.92 Very High Very High Very High
Targeted Disruption 25 95.00 High High
Increased Venous Pressure Under Development 66 94.04 High High
Pain 15 90.12 High High
Pressure And Volume Under Development 2 87.64 High High
Hypertension 24 84.64 Quite High
Embryonal Carcinoma 7 80.72 Quite High
Nociception 26 72.88 Quite High
Stroke 8 43.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together these data imply that activation of P2Y2/P2Y4 receptors on astrocytes causes inhibition of SCO.
Positive_regulation (activation) of P2Y4 in astrocytes
1) Confidence 0.27 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.03
UTP activates three P2Y receptors: P2Y2 receptor that is activated equipotently by ATP and UTP, P2Y4 receptor most potently activated by UTP, and the P2Y6 receptor that can be selectively activated by UDP.
Positive_regulation (activates) of P2Y2 receptor
2) Confidence 0.20 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.30
Overall the data shown in Fig. 8 provide the evidence for attenuation of neurotransmitter release by NO produced as a result of P2Y receptor activation.


Positive_regulation (activation) of P2Y receptor associated with neurotransmitter
3) Confidence 0.18 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.23
Differential expression and activity of P2Y1, P2Y2, P2Y4, P2X2 subtypes and P2X6 subunits were reported during neuronal maturation of P19 cells [38, 39].
Positive_regulation (activity) of P2Y4 in P19
4) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.27 Pain Relevance 0.11
The P2X4 receptor protein is upregulated in the placenta in preeclampsia [89].
Positive_regulation (upregulated) of P2X4 receptor in placenta associated with pre-eclampsia
5) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.19 Pain Relevance 0.07
In the cardiovascular system, activation of P2X4 receptor increases cardiac contractility [45].
Positive_regulation (activation) of P2X4 receptor in cardiovascular system
6) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.42 Pain Relevance 0.34

General Comments

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