INT196870

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.43
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 3 98.76 Very High Very High Very High
adenocard 4 97.64 Very High Very High Very High
bradykinin 8 96.72 Very High Very High Very High
substance P 10 95.56 Very High Very High Very High
Calcitonin gene-related peptide 14 94.84 High High
Neuropeptide 6 92.20 High High
Calcium channel 9 90.44 High High
agonist 11 87.20 High High
ischemia 10 83.88 Quite High
Pain 13 78.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 42 99.84 Very High Very High Very High
Calcification 59 99.16 Very High Very High Very High
Diabetes Mellitus 5 97.76 Very High Very High Very High
Chronic Renal Failure 2 97.28 Very High Very High Very High
Disease 10 91.84 High High
Renal Failure 2 91.52 High High
Sclerosis 1 89.32 High High
Atherosclerosis 21 86.60 High High
Cv Unclassified Under Development 6 83.88 Quite High
Pain 12 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, because more than one type of Ca2+-acitvated Cl?
Positive_regulation (because) of Phosphorylation (type) of Ca2
1) Confidence 0.26 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0
Increases in intracellular Ca2+ initiate several second messenger pathways, including activation of PLA2, PLC and Ca2+-dependent kinases, which can lead to the generation of AA and its metabolites, release of Ca2+ from intracellular stores, and phosphorylation of nociceptive receptors, respectively.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Ca2 associated with nociception
2) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.83 Pain Relevance 1.09
Increases in intracellular Ca2+ initiate several second messenger pathways, including activation of PLA2, PLC and Ca2+-dependent kinases, which can lead to the generation of AA and its metabolites, release of Ca2+ from intracellular stores, and phosphorylation of nociceptive receptors, respectively.
Positive_regulation (lead) of Phosphorylation (phosphorylation) of Ca2 associated with nociception
3) Confidence 0.07 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.80 Pain Relevance 1.04
In contrast, Tian et al. suggested that the increase in the slow after-hyperpolarization amplitude seen after exposure to high doses of corticosterone may involve cAMP-dependent phosphorylation and Ca2+-activated K+ channels [102]: dexamethasone (1 ?
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of Ca2 associated with dexamethasone
4) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.06 Pain Relevance 0.42
Another recent study does not entirely support the hypothesis on the role of PP-1, as they have some evidence that CaMK-II modulation of GABAA receptors critically requires Ca2+/CaM binding to CaMK-II but not autophosphorylation (C.
Positive_regulation (requires) of Neg (not) Phosphorylation (autophosphorylation) of Ca2
5) Confidence 0.06 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08
phosphorus and increased ion product [Ca2+×PO4?
Positive_regulation (increased) of Phosphorylation (phosphorus) of Ca2
6) Confidence 0.04 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.73 Pain Relevance 0

General Comments

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