INT196872

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.47
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
blood 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 14 100.00 Very High Very High Very High
Glutamate 10 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 99.84 Very High Very High Very High
substance P 21 99.48 Very High Very High Very High
qutenza 136 99.14 Very High Very High Very High
Inflammation 28 93.68 High High
ischemia 14 92.00 High High
Deafferentation 1 86.64 High High
antagonist 40 85.52 High High
bradykinin 14 79.36 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 99.96 Very High Very High Very High
INFLAMMATION 32 93.68 High High
Coronary Artery Disease 6 92.88 High High
Colitis 2 85.20 High High
Pancreatitis 2 81.68 Quite High
Clostridium Difficile Infection 1 80.08 Quite High
Cv Unclassified Under Development 8 77.92 Quite High
Nociception 58 68.96 Quite High
Diabetes Mellitus 8 54.24 Quite High
Inflammatory Bowel Disease 1 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV1 mediated CGRP release could play a role in increasing blood supply to malignancies of the GI tract; the beneficial effect of COX inhibitors in this regard may arise from their ability to reduce TRPV1-mediated CGRP release and inhibition of PG-mediated angiogenesis.
Negative_regulation (reduce) of Localization (release) of TRPV1 in blood associated with calcitonin gene related peptide
1) Confidence 0.42 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.61 Pain Relevance 0.89
Thus, the effects of both capsaicin and capsazepine appear to be presynaptic, reducing glutamate release from excitatory terminals both in wild type and TRPV1R knockout mice.
Negative_regulation (reducing) of Localization (release) of TRPV1R associated with targeted disruption, glutamate and qutenza
2) Confidence 0.37 Published 2008 Journal Neurochem Int Section Body Doc Link PMC2194163 Disease Relevance 0.10 Pain Relevance 0.85
We propose that reduction of PG levels may contribute to deleterious vascular effects by decreasing sensitization of TRPV1 and subsequent reduction of CGRP and SP release.
Negative_regulation (reduction) of Localization (sensitization) of TRPV1 associated with substance p and calcitonin gene-related peptide
3) Confidence 0.29 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.38 Pain Relevance 0.63
We propose that reduction of PG levels may contribute to deleterious vascular effects by decreasing sensitization of TRPV1 and subsequent reduction of CGRP and SP release.
Negative_regulation (decreasing) of Localization (sensitization) of TRPV1 associated with substance p and calcitonin gene-related peptide
4) Confidence 0.29 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.38 Pain Relevance 0.62

General Comments

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