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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Ly6 (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 8 100.00 Very High Very High Very High
long-term potentiation 63 81.76 Quite High
cOX1 5 81.36 Quite High
COX2 10 72.24 Quite High
Central nervous system 1 67.28 Quite High
nociceptor 6 50.00 Quite Low
Calcium channel 1 48.68 Quite Low
Hippocampus 10 41.28 Quite Low
potassium channel 6 31.20 Quite Low
agonist 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 92.40 High High
Nociception 21 85.40 High High
Ganglion Cysts 1 74.32 Quite High
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAG activates protein kinase C (PKC) and DAG lipase, activation of DAG lipase can in turn produce AA.
DAG Positive_regulation (activates) of PKC associated with kinase c
1) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.18 Pain Relevance 0.25
Gq/11 subunits' downstream signaling bifurcates into the production of IP3 and DAG, which has been shown to promote Ca2+ release from intracellular stores, activate PKC, and locally deplete PIP2 levels (Delmas and Brown, 2005).
DAG Positive_regulation (activate) of PKC
2) Confidence 0.01 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0.07 Pain Relevance 0.17

General Comments

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