INT196914

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (E2f2) cell cycle (E2f2) DNA binding (E2f2)
transcription factor binding (E2f2)
Anatomy Link Frequency
glands 1
E2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 10 42.88 Quite Low
Hippocampus 9 28.80 Quite Low
depression 2 9.12 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 98.64 Very High Very High Very High
Adenoma 4 96.12 Very High Very High Very High
Pituitary Cancer 27 92.04 High High
Necrosis 1 89.24 High High
Cancer 4 88.88 High High
Targeted Disruption 12 86.60 High High
Aging 39 68.84 Quite High
Genetic Predisposition To Disease 4 68.60 Quite High
Sprains And Strains 4 59.12 Quite High
Autoimmune Disease 15 47.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E2f2 is the best candidate in this region considering that mice deficient for both E2F1 and E2F2 develop nonautoimmune, insulin-dependent diabetes with high penetrance [57].
Gene_expression (develop) of E2F2 associated with diabetes mellitus
1) Confidence 0.58 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.74 Pain Relevance 0
Moreover, by RT-PCR and ChIPs on tissues, expression of E2F-target genes, such as CDC1 and TK1, was shown to be enhanced, and E2F1 to be more acetylated in adenomas compared to normal glands (unpublished data).
Gene_expression (expression) of E2F in glands associated with adenoma
2) Confidence 0.01 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.79 Pain Relevance 0
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Spec (appears) Gene_expression (include) of E2F
3) Confidence 0.01 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0

General Comments

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