INT196915

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.82
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (E2f2) cell cycle (E2f2) DNA binding (E2f2)
transcription factor binding (E2f2)
Anatomy Link Frequency
pituitary 1
E2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 94.12 High High
Inflammatory response 1 90.64 High High
Inflammatory mediators 1 67.84 Quite High
agonist 4 19.68 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pituitary Cancer 54 97.96 Very High Very High Very High
INFLAMMATION 31 94.12 High High
Targeted Disruption 22 90.64 High High
Cancer 7 90.36 High High
Lung Injury 40 88.64 High High
Pressure And Volume Under Development 1 86.84 High High
Adenoma 8 86.40 High High
Sprains And Strains 2 71.52 Quite High
Necrosis 1 63.20 Quite High
Syndrome 6 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, a group of genes upregulated by HTV mechanical ventilation alone (ETF, E2F, Nrf1, CREB, and HIF1) is not found in the list of genes upregulated by LPS [49].
Positive_regulation (upregulated) of E2F
1) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 1.23 Pain Relevance 0.20
Interestingly, even in pituitary adenomas developed by HMGA2 mice lacking E2F1 the interaction between HMGA2 and pRB was present, however, the E2F "free" DNA binding activity did not show any significant increase compared to control wild-type glands.
Positive_regulation (increase) of E2F in pituitary associated with pituitary cancer
2) Confidence 0.01 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.86 Pain Relevance 0
The data obtained showed a drastic increase of the "free" active form of the E2F/DNA complex.
Positive_regulation (increase) of E2F
3) Confidence 0.01 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.73 Pain Relevance 0

General Comments

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