INT196916

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 14.29
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) cell cycle (Rb1)
DNA binding (Rb1) cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
RG2 2
pituitary 1
DBTRG-05MG 1
Rb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 5 92.12 High High
imagery 82 90.12 High High
Angina 12 70.60 Quite High
Inflammation 3 41.20 Quite Low
Central nervous system 14 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 648 100.00 Very High Very High Very High
Retinoblastoma 12 100.00 Very High Very High Very High
Repression 9 100.00 Very High Very High Very High
Shock 4 100.00 Very High Very High Very High
Targeted Disruption 129 99.88 Very High Very High Very High
Genomic Instability 1 99.60 Very High Very High Very High
Retinal Degeneration 9 98.76 Very High Very High Very High
Pituitary Cancer 138 97.96 Very High Very High Very High
Death 27 97.08 Very High Very High Very High
Malignant Neoplastic Disease 54 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conditional knockout mice deficient in retinal retinoblastoma protein Rb, the gradient of Cre expression from center to periphery, leading to a gradual reduction of retinal thickness, was clearly visible and well topographically quantifiable.
Negative_regulation (deficient) of retinoblastoma associated with targeted disruption and retinoblastoma
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759518 Disease Relevance 0.63 Pain Relevance 0.04
More recently, Matoso and colleagues[25] have shown that loss of the wild-type retinoblastoma 1 (Rb) gene may lead to MEN-like phenotype in Rb mice.
Spec (like) Negative_regulation (loss) of retinoblastoma 1 associated with retinoblastoma
2) Confidence 0.42 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.73 Pain Relevance 0
More recently, a new mechanism of pRB-mediated E2F1 repression has been suggested in addition to this one.
Negative_regulation (repression) of pRB associated with repression
3) Confidence 0.38 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.48 Pain Relevance 0
Despite the somewhat lower resolution achievable in living tissues, the changes in retinal layering and thickness associated with Rb gene loss appeared equally well ascertainable with histology and OCT (Figure 6 A vs.
Negative_regulation (loss) of Rb
4) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759518 Disease Relevance 0.21 Pain Relevance 0
In conditional knockout mice deficient in retinal retinoblastoma protein Rb, the gradient of Cre expression from center to periphery, leading to a gradual reduction of retinal thickness, was clearly visible and well topographically quantifiable.
Negative_regulation (deficient) of Rb associated with targeted disruption and retinoblastoma
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759518 Disease Relevance 0.64 Pain Relevance 0.04
More recently, Matoso and colleagues[25] have shown that loss of the wild-type retinoblastoma 1 (Rb) gene may lead to MEN-like phenotype in Rb mice.
Spec (like) Negative_regulation (loss) of Rb associated with retinoblastoma
6) Confidence 0.19 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2678126 Disease Relevance 1.73 Pain Relevance 0
The transforming activities of E6 and E7 correlate, at least in part, with the inactivation of two cellular tumor suppressor gene products, p53 and pRb, which regulate the processes of cell division, differentiation, and/or death [11-14].
Negative_regulation (inactivation) of pRb associated with cancer and death
7) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.77 Pain Relevance 0
They showed that by crossbreeding Rb (+/-) mice with knockout mice, the development of pituitary tumors could be delayed.
Negative_regulation (crossbreeding) of Rb in pituitary associated with targeted disruption and pituitary cancer
8) Confidence 0.10 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.80 Pain Relevance 0
Therefore, the decrease in phosphorylated Rb should be due to a BP-triggered expression of the cdk inhibitors, which decreases the activities of the cyclin/cdk complex.
Negative_regulation (decrease) of Rb
9) Confidence 0.03 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.55 Pain Relevance 0
Two genes of this group, E1A and E1B, act in inactivating tumor suppressor Rb and p53 genes that are frequently mutated in cancer cells [7].
Negative_regulation (inactivating) of Rb associated with cancer
10) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.46 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Negative_regulation (decrease) of Rb in DBTRG-05MG
11) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.71 Pain Relevance 0.16
However, levels of phosphorylated Rb proteins were decreased after BP treatment in DBTRG-05MG and DBTRG 8401 cells; in RG2 cells, the levels were decreased (0.8-fold) at 1.5 h, with phosphorylated proteins undetectable as early as 3 h after BP treatment (Fig. 2a).
Negative_regulation (decreased) of Rb in RG2
12) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.56 Pain Relevance 0
In the short time following its discovery, NCoA6 has emerged as an important coactivator not only for NRs, but also for a number of other well known transcription factors such as c-Fos, c-Jun, CREB, NF-kB, ATF-2, heat shock factors, E2F-1, SRF, Rb, p53 and Stat2 [Goo et al., 2004; Hong et al., 2004a; Hong et al., 2004b; Ko et al., 2000; Kong et al., 2003; Lee et al., 1999; Lee et al., 2000; Mahajan et al., 2007; Mahajan et al., 2002; Mahajan and Samuels, 2000; Mahajan and Samuels, 2005].
Negative_regulation (number) of Rb associated with shock
13) Confidence 0.02 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.40 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Negative_regulation (decrease) of Rb in RG2
14) Confidence 0.01 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.71 Pain Relevance 0.16
It has been reported that the combined loss of p53 function and RB1 protein leads to genomic instability, a finding consistent with the model of progressive accumulation of genetic changes with increasing malignancy [68,70].
Negative_regulation (loss) of RB1 protein associated with malignant neoplastic disease and genomic instability
15) Confidence 0.01 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 0.92 Pain Relevance 0

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