INT196917

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 3.66
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac1) nucleus (Hdac1) enzyme binding (Hdac1)
DNA binding (Hdac1) protein complex (Hdac1) transcription factor binding (Hdac1)
Anatomy Link Frequency
embryos 8
oocytes 3
spinal cord 1
Hdac1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 39 99.98 Very High Very High Very High
Pain 14 64.08 Quite High
Inflammation 8 50.00 Quite Low
Central nervous system 2 26.08 Quite Low
IPN 5 19.20 Low Low
Lasting pain 12 18.04 Low Low
fibrosis 30 5.00 Very Low Very Low Very Low
Hyperalgesia 17 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 180 97.96 Very High Very High Very High
Apoptosis 130 96.56 Very High Very High Very High
Polycystic Ovary Syndrome 42 91.00 High High
Cancer 127 90.28 High High
Ovarian Hyperstimulation Syndrome 28 89.32 High High
Pituitary Cancer 27 86.08 High High
Retinoblastoma 2 83.04 Quite High
Pain 27 64.08 Quite High
Repression 7 60.96 Quite High
Nociception 18 55.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduced level of HDAC1 protein expression in nuclei of IVM 2-cell embryos suggested that IVM affected the HDAC1 protein syntheses and might interrupt its nucleus-cytoplasm distributions at this stage of embryos [20].
Gene_expression (expression) of HDAC1 protein in embryos
1) Confidence 0.71 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
No differences were detected in the expression of GCN5 and HDAC1 after two-cell stage embryos, which indicated that the insufficiency induced by IVM might be rectified during the process of growing from two-cell to four-cell stage.
Gene_expression (expression) of HDAC1 in embryos
2) Confidence 0.71 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
Although IVM could affect the expression and distribution of GCN5 and HDAC1 in MII oocytes and 2-cell embryos, which might be one reason for the low BR after 2-cell transfer, the levels of acetyl-histone H3 were not significantly changed in IVM group.
Gene_expression (expression) of HDAC1 in embryos
3) Confidence 0.71 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
In conclusion, our studies showed that IVM could affect the expressions of GCN5 and HDAC1 in MII oocytes and two-cell embryos.
Gene_expression (expressions) of HDAC1 in embryos
4) Confidence 0.71 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
The HDAC1 mRNA was expressed in both MII oocytes and embryos.
Gene_expression (expressed) of HDAC1 mRNA in embryos
5) Confidence 0.71 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
The seeming inconsistency between GCN5/HDAC1 levels and H3 acetylation levels is partially caused by protein localization, as IVM-induced changes of GCN5 were observed in the cytoplasm, while Ac-H3 is associated with chromatins that localize in nuclei.
Gene_expression (levels) of HDAC1
6) Confidence 0.62 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
The reduced level of HDAC1 protein expression in nuclei of IVM 2-cell embryos suggested that IVM affected the HDAC1 protein syntheses and might interrupt its nucleus-cytoplasm distributions at this stage of embryos [20].
Gene_expression (syntheses) of HDAC1 protein in embryos
7) Confidence 0.62 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
We determined the expression and distribution of GCN5, HDAC1, and Ac-H3 in metaphase II oocytes matured in vitro and in vivo.
Spec (determined) Gene_expression (expression) of HDAC1 in oocytes
8) Confidence 0.62 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
The precise mechanisms by which IVM affect, the GCN5 and HDAC1 levels and the implication of these changes for the safety of offspring need to be investigated in future studies.



Gene_expression (levels) of HDAC1
9) Confidence 0.62 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
Overexpression of HDAC1 could cause aberrant morphologies and a partial blockage in the G2/M phases of the cell cycle [21].
Gene_expression (Overexpression) of HDAC1
10) Confidence 0.62 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
To investigate the influences of IVM on epigenetic reprogramming and to search for the possible reasons for the lower rates of fertilization and cleavage in IVM oocytes, we examined the expression of two enzymes controlling histone acetylation, histone acetyltransferase GCN5 (GCN5) and histone deacetylase 1 (HDAC1), as well as their common target, acetyl-histone H3 (Ac-H3), in mouse metaphase II (MII) oocytes and preimplantation embryos.
Spec (examined) Gene_expression (expression) of HDAC1 in oocytes
11) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Abstract Doc Link PMC2896857 Disease Relevance 0.27 Pain Relevance 0
The low rate of developmental competence from two-cell to four-cell embryos could be explained by the delay of zygotic gene activation (ZGA) associated with expression alteration of HDAC1 and/or other genes [40].
Gene_expression (expression) of HDAC1 in embryos
12) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
Expression of HDAC1 mRNA in MII oocytes and two-cell embryos decreased in the IVM group.
Gene_expression (Expression) of HDAC1 mRNA in embryos
13) Confidence 0.55 Published 2010 Journal Obstetrics and Gynecology International Section Abstract Doc Link PMC2896857 Disease Relevance 0.22 Pain Relevance 0
For example, the spinal cord expresses the genes of HDAC1~8, and 11 [25-27].
Gene_expression (expresses) of HDAC1 in spinal cord associated with spinal cord
14) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.22 Pain Relevance 0.28
This interaction was then repeated and confirmed in vitro with recombinant proteins, finding that one of the pRB domains involved in the interaction is the A/B pocket [30], the same domain that is also involved in the interaction with E2F1, HDAC1 and viral oncoproteins such as those produced by the E1A adenovirus [39,40].
Gene_expression (produced) of HDAC1
15) Confidence 0.38 Published 2006 Journal Cell Div Section Body Doc Link PMC1563461 Disease Relevance 0.38 Pain Relevance 0
As primary antibodies, a rabbit polyclonal HDAC1 antibody (1:5000) (Santa Cruz Biotechnology Inc., Santa Cruz, CA), rabbit polyclonal HDAC2 antibody (1:5000) (Santa Cruz), rabbit polyclonal acetyl-histone H3 (Lys 9) antibody (1:5000) (Cell Signaling, Beverly, MA), mouse monoclonal acetyl ?
Gene_expression (antibody) of HDAC1
16) Confidence 0.38 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.35 Pain Relevance 0
Expression of HDAC1 and HDAC2 in OCUM-2MD3 cells
Gene_expression (Expression) of HDAC1
17) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.53 Pain Relevance 0
Immunohistologically, both HDAC1 and HDAC2 were expressed mainly in nuclei.
Gene_expression (expressed) of HDAC1
18) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.51 Pain Relevance 0
HDAC1 and HDAC2 expression were evaluated by western blotting in OCUM-2MD3 cells and other gastric cancer cell lines (TMK-1, MKN-28).
Gene_expression (expression) of HDAC1 associated with stomach cancer
19) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.57 Pain Relevance 0
OCUM-2MD3 cells showed high levels of HDAC1 and HDAC2 expression compared with TMK-1 and MKN-28.
Gene_expression (expression) of HDAC1
20) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.61 Pain Relevance 0

General Comments

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